Seroatlas · Human Serome Atlas

PPP2R5C

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

Also known as: 2A5G_HUMAN, B56G, B56gamma, PR61G

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13362
Gene: PPP2R5C
Ensembl: ENSG00000078304
Chromosome: 14
Canonical length: 524 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

524 residues, UniProt reviewed canonical sequence.

>Q13362|PPP2R5C
     1  MLTCNKAGSR MVVDAANSNG PFQPVVLLHI RDVPPADQEK LFIQKLRQCC VLFDFVSDPL
    61  SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA VNMFRTLPPS SNPTGAEFDP
   121  EEDEPTLEAA WPHLQLVYEF FLRFLESPDF QPNIAKKYID QKFVLQLLEL FDSEDPRERD
   181  FLKTTLHRIY GKFLGLRAYI RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK
   241  EEHKIFLLKV LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK
   301  EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW NNEYIMSLIS
   361  DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM NQKLFDDCTQ QFKAEKLKEK
   421  LKMKEREEAW VKIENLAKAN PQYTVYSQAS TMSIPVAMET DGPLFEDVQM LRKTVKDEAH
   481  QAQKDPKKDR PLARRKSELP QDPHTKKALE AHCRADELAS QDGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP2R5C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 127 nTPM

Expression across tissuesHPA

Tissue

lymph node: 127 nTPM
bone marrow: 121 nTPM
tonsil: 115 nTPM
thymus: 106 nTPM
heart muscle: 103 nTPM
amygdala: 94 nTPM

Single-cell type

t-cells: 951 nCPM
nk-cells: 889 nCPM
neutrophils: 604 nCPM
cardiomyocytes: 400 nCPM
b-cells: 326 nCPM
neutrophil progenitors: 301 nCPM

Immune cell

gdT-cell: 217 nTPM
memory CD8 T-cell: 171 nTPM
T-reg: 156 nTPM
naive CD8 T-cell: 153 nTPM
memory CD4 T-cell: 140 nTPM
MAIT T-cell: 139 nTPM

Brain region

hippocampal formation: 152 nTPM
cerebral cortex: 127 nTPM
spinal cord: 124 nTPM
medulla oblongata: 121 nTPM
basal ganglia: 121 nTPM
white matter: 120 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PPP2R5C.

Disease | AllUniProt

Conditions PPP2R5C is implicated in, by any mechanism.

Houge-Janssens syndrome 4 (HJS4) MIM:621185

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 154 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Houge-Janssens syndrome 4
Global developmental delay
See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 3.08
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP2R5C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP2R5C as an antibody target. Whether an autoantibody or antibody against PPP2R5C could matter depends on whether native PPP2R5C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP2R5C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP2R5C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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