Seroatlas · Human Serome Atlas

PIM3

Serine/threonine-protein kinase pim-3

Also known as: PIM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86V86
Gene: PIM3
Ensembl: ENSG00000198355
Chromosome: 22
Canonical length: 326 aa
Protein class: Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>Q86V86|PIM3
     1  MLLSKFGSLA HLCGPGGVDH LPVKILQPAK ADKESFEKAY QVGAVLGSGG FGTVYAGSRI
    61  ADGLPVAVKH VVKERVTEWG SLGGATVPLE VVLLRKVGAA GGARGVIRLL DWFERPDGFL
   121  LVLERPEPAQ DLFDFITERG ALDEPLARRF FAQVLAAVRH CHSCGVVHRD IKDENLLVDL
   181  RSGELKLIDF GSGALLKDTV YTDFDGTRVY SPPEWIRYHR YHGRSATVWS LGVLLYDMVC
   241  GDIPFEQDEE ILRGRLLFRR RVSPECQQLI RWCLSLRPSE RPSLDQIAAH PWMLGADGGV
   301  PESCDLRLCT LDPDDVASTT SSSESL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 129 nTPM

Expression across tissuesHPA

Tissue

stomach: 129 nTPM
skin: 127 nTPM
skeletal muscle: 122 nTPM
kidney: 120 nTPM
lung: 118 nTPM
bone marrow: 108 nTPM

Single-cell type

extravillous trophoblasts: 461 nCPM
syncytiotrophoblasts: 458 nCPM
prostatic club cells: 352 nCPM
esophageal apical cells: 318 nCPM
urothelial cells: 298 nCPM
prostatic hillock cells: 246 nCPM

Immune cell

neutrophil: 21 nTPM
naive B-cell: 7.5 nTPM
plasmacytoid DC: 7 nTPM
T-reg: 5.8 nTPM
non-classical monocyte: 5.2 nTPM
memory CD4 T-cell: 5 nTPM

Brain region

medulla oblongata: 71 nTPM
white matter: 68 nTPM
cerebral cortex: 66 nTPM
pons: 64 nTPM
thalamus: 61 nTPM
midbrain: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.98
gnomAD missense Z: 0.92
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIM3 as an antibody target. Whether an autoantibody or antibody against PIM3 could matter depends on whether native PIM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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