Metallo-dependent phosphatase-like
IPR029052
Definition
This entry represents a domain found in metallo-dependent phosphatases. Proteins containing this domain include: Purple acid phosphatases PMID:10438611. DNA double-strand break repair nucleases PMID:11371344. 5'-nucleotidases (syn. UDP-sugar hydrolase). Protein serine/threonine phosphatase. Phosphoesterase-related proteins. TT1561-like proteins. YfcE-like proteins. Hypothetical protein aq_1666. DR1281-like proteins. TTHA0625-like proteins. GpdQ-like proteins. ADPRibase-Mn-like proteins. Metallophosphatases (MPPs), also known as metallophosphoesterases, phosphodiesterases (PDEs), binuclear metallophosphoesterases, and dimetal-containing phosphoesterases (DMPs), represent a diverse superfamily of enzymes with a conserved domain containing an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues [[cite:PMID:18757371], [cite:PMID:25837850]].
29 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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