Seroatlas · Human Serome Atlas

TRAF3IP3

TRAF3-interacting JNK-activating modulator

Also known as: T3JAM, T3JAM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y228
Gene
TRAF3IP3
Ensembl
ENSG00000009790
Chromosome
1
Canonical length
551 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

551 residues, UniProt reviewed canonical sequence.

>Q9Y228|TRAF3IP3
     1  MISPDPRPSP GLARWAESYE AKCERRQEIR ESRRCRPNVT TCRQVGKTLR IQQREQLQRA
    61  RLQQFFRRRN LELEEKGKAQ HPQAREQGPS RRPGQVTVLK EPLSCARRIS SPREQVTGTS
   121  SEVFPAQHPP PSGICRDLSD HLSSQAGGLP PQDTPIKKPP KHHRGTQTKA EGPTIKNDAS
   181  QQTNYGVAVL DKEIIQLSDY LKEALQRELV LKQKMVILQD LLSTLIQASD SSWKGQLNED
   241  KLKGKLRSLE NQLYTCTQKY SPWGMKKVLL EMEDQKNSYE QKAKESLQKV LEEKMNAEQQ
   301  LQSTQRSLAL AEQKCEEWRS QYEALKEDWR TLGTQHRELE SQLHVLQSKL QGADSRDLQM
   361  NQALRFLENE HQQLQAKIEC LQGDRDLCSL DTQDLQDQLK RSEAEKLTLV TRVQQLQGLL
   421  QNQSLQLQEQ EKLLTKKDQA LPVWSPKSFP NEVEPEGTGK EKDWDLRDQL QKKTLQLQAK
   481  EKECRELHSE LDNLSDEYLS CLRKLQHCRE ELNQSQQLPP RRQCGRWLPV LMVVIAAALA
   541  VFLANKDNLM I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAF3IP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
122 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 122 nTPM
  • lymph node: 93 nTPM
  • tonsil: 85 nTPM
  • spleen: 57 nTPM
  • appendix: 49 nTPM
  • bone marrow: 30 nTPM

Single-cell type

  • neutrophils: 326 nCPM
  • t-cells: 180 nCPM
  • nk-cells: 177 nCPM
  • neutrophil progenitors: 153 nCPM
  • endometrial luminal cells: 142 nCPM
  • microglia: 138 nCPM

Immune cell

  • T-reg: 589 nTPM
  • naive CD4 T-cell: 461 nTPM
  • basophil: 459 nTPM
  • total PBMC: 415 nTPM
  • memory CD4 T-cell: 412 nTPM
  • naive CD8 T-cell: 366 nTPM

Brain region

  • cerebral cortex: 9 nTPM
  • white matter: 7.2 nTPM
  • medulla oblongata: 5.8 nTPM
  • thalamus: 5.7 nTPM
  • pons: 5.6 nTPM
  • midbrain: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
0.71
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAF3IP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAF3IP3 as an antibody target. Whether an autoantibody or antibody against TRAF3IP3 could matter depends on whether native TRAF3IP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAF3IP3 is annotated at the cell surface, where native TRAF3IP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRAF3IP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAF3IP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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