Seroatlas · Human Serome Atlas

ZFP36

mRNA decay activator protein ZFP36

Also known as: G0S24, NUP475, RNF162A, TIS11, TTP, TTP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P26651
Gene
ZFP36
Ensembl
ENSG00000128016
Chromosome
19
Canonical length
326 aa
Protein class
Predicted intracellular proteins
Subcellular location
Intermediate filaments

OverviewNCBI Gene

Enables several functions, including 14-3-3 protein binding activity; mRNA 3'-UTR AU-rich region binding activity; and protein-RNA sequence-specific adaptor activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to epidermal growth factor stimulus; and regulation of gene expression. Acts upstream of or within mRNA catabolic process. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Part of ribonucleoprotein complex. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>P26651|ZFP36
     1  MDLTAIYESL LSLSPDVPVP SDHGGTESSP GWGSSGPWSL SPSDSSPSGV TSRLPGRSTS
    61  LVEGRSCGWV PPPPGFAPLA PRLGPELSPS PTSPTATSTT PSRYKTELCR TFSESGRCRY
   121  GAKCQFAHGL GELRQANRHP KYKTELCHKF YLQGRCPYGS RCHFIHNPSE DLAAPGHPPV
   181  LRQSISFSGL PSGRRTSPPP PGLAGPSLSS SSFSPSSSPP PPGDLPLSPS AFSAAPGTPL
   241  ARRDPTPVCC PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE
   301  AGVFAPPQPV AAPRRLPIFN RISVSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
1,477 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 1,477 nTPM
  • lung: 1,096 nTPM
  • fallopian tube: 942 nTPM
  • skin: 810 nTPM
  • breast: 719 nTPM
  • bone marrow: 704 nTPM

Single-cell type

  • decidual stromal cells: 4,942 nCPM
  • esophageal apical cells: 4,461 nCPM
  • epididymal basal cells: 3,050 nCPM
  • ovarian stromal cells: 2,957 nCPM
  • neutrophils: 2,521 nCPM
  • smooth muscle cells: 2,012 nCPM

Immune cell

  • neutrophil: 315 nTPM
  • basophil: 123 nTPM
  • non-classical monocyte: 96 nTPM
  • classical monocyte: 72 nTPM
  • intermediate monocyte: 70 nTPM
  • myeloid DC: 69 nTPM

Brain region

  • medulla oblongata: 243 nTPM
  • thalamus: 151 nTPM
  • hypothalamus: 148 nTPM
  • spinal cord: 137 nTPM
  • white matter: 135 nTPM
  • choroid plexus: 118 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.75
gnomAD missense Z
0.79
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFP36 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP36 as an antibody target. Whether an autoantibody or antibody against ZFP36 could matter depends on whether native ZFP36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZFP36. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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