Seroatlas · Human Serome Atlas

SMG5

Nonsense-mediated mRNA decay factor SMG5

Also known as: EST1B, KIAA1089, LPTS-RP1, LPTSRP1, RP11-54H19.7, SMG-5, SMG5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UPR3
Gene
SMG5
Ensembl
ENSG00000198952
Chromosome
1
Canonical length
1016 aa
Protein class
Predicted membrane proteins
Subcellular location
Cytoplasmic bodies

OverviewNCBI Gene

SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1016 residues, UniProt reviewed canonical sequence.

>Q9UPR3|SMG5
     1  MSQGPPTGES SEPEAKVLHT KRLYRAVVEA VHRLDLILCN KTAYQEVFKP ENISLRNKLR
    61  ELCVKLMFLH PVDYGRKAEE LLWRKVYYEV IQLIKTNKKH IHSRSTLECA YRTHLVAGIG
   121  FYQHLLLYIQ SHYQLELQCC IDWTHVTDPL IGCKKPVSAS GKEMDWAQMA CHRCLVYLGD
   181  LSRYQNELAG VDTELLAERF YYQALSVAPQ IGMPFNQLGT LAGSKYYNVE AMYCYLRCIQ
   241  SEVSFEGAYG NLKRLYDKAA KMYHQLKKCE TRKLSPGKKR CKDIKRLLVN FMYLQSLLQP
   301  KSSSVDSELT SLCQSVLEDF NLCLFYLPSS PNLSLASEDE EEYESGYAFL PDLLIFQMVI
   361  ICLMCVHSLE RAGSKQYSAA IAFTLALFSH LVNHVNIRLQ AELEEGENPV PAFQSDGTDE
   421  PESKEPVEKE EEPDPEPPPV TPQVGEGRKS RKFSRLSCLR RRRHPPKVGD DSDLSEGFES
   481  DSSHDSARAS EGSDSGSDKS LEGGGTAFDA ETDSEMNSQE SRSDLEDMEE EEGTRSPTLE
   541  PPRGRSEAPD SLNGPLGPSE ASIASNLQAM STQMFQTKRC FRLAPTFSNL LLQPTTNPHT
   601  SASHRPCVNG DVDKPSEPAS EEGSESEGSE SSGRSCRNER SIQEKLQVLM AEGLLPAVKV
   661  FLDWLRTNPD LIIVCAQSSQ SLWNRLSVLL NLLPAAGELQ ESGLALCPEV QDLLEGCELP
   721  DLPSSLLLPE DMALRNLPPL RAAHRRFNFD TDRPLLSTLE ESVVRICCIR SFGHFIARLQ
   781  GSILQFNPEV GIFVSIAQSE QESLLQQAQA QFRMAQEEAR RNRLMRDMAQ LRLQLEVSQL
   841  EGSLQQPKAQ SAMSPYLVPD TQALCHHLPV IRQLATSGRF IVIIPRTVID GLDLLKKEHP
   901  GARDGIRYLE AEFKKGNRYI RCQKEVGKSF ERHKLKRQDA DAWTLYKILD SCKQLTLAQG
   961  AGEEDPSGMV TIITGLPLDN PSVLSGPMQA ALQAAAHASV DIKNVLDFYK QWKEIG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMG5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 60 nTPM
  • heart muscle: 55 nTPM
  • liver: 46 nTPM
  • kidney: 45 nTPM
  • bone marrow: 44 nTPM
  • parathyroid gland: 44 nTPM

Single-cell type

  • endometrial luminal cells: 129 nCPM
  • cone photoreceptor cells: 104 nCPM
  • esophageal apical cells: 82 nCPM
  • salivary basal cells: 77 nCPM
  • adrenal medulla cells: 75 nCPM
  • myonuclei: 70 nCPM

Immune cell

  • eosinophil: 5.2 nTPM
  • non-classical monocyte: 4.2 nTPM
  • neutrophil: 4.1 nTPM
  • intermediate monocyte: 3.9 nTPM
  • gdT-cell: 3.8 nTPM
  • classical monocyte: 3.7 nTPM

Brain region

  • white matter: 76 nTPM
  • thalamus: 73 nTPM
  • medulla oblongata: 73 nTPM
  • cerebral cortex: 72 nTPM
  • midbrain: 71 nTPM
  • pons: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.01
gnomAD missense Z
1.13
DepMap mean gene effect
-1.04
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMG5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMG5 as an antibody target. Whether an autoantibody or antibody against SMG5 could matter depends on whether native SMG5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMG5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMG5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMG5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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