Seroatlas · Human Serome Atlas

PABIR1

PPP2R1A-PPP2R2A-interacting phosphatase regulator 1

Also known as: C9orf42, FAM122A, MGC17347, PBIR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96E09
Gene: PABIR1
Ensembl: ENSG00000187866
Chromosome: 9
Canonical length: 287 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables protein phosphatase 2A binding activity and protein serine/threonine phosphatase inhibitor activity. Involved in mitotic G2/M transition checkpoint; positive regulation of cell growth; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q96E09|PABIR1
     1  MAQEKMELDL ELPPGTGGSP AEGGGSGGGG GLRRSNSAPL IHGLSDTSPV FQAEAPSARR
    61  NSTTFPSRHG LLLPASPVRM HSSRLHQIKQ EEGMDLINRE TVHEREVQTA MQISHSWEES
   121  FSLSDNDVEK SASPKRIDFI PVSPAPSPTR GIGKQCFSPS LQSFVSSNGL PPSPIPSPTT
   181  RFTTRRSQSP INCIRPSVLG PLKRKCEMET EYQPKRFFQG ITNMLSSDVA QLSDPGVCVS
   241  SDTLDGNSSS AGSSCNSPAK VSTTTDSPVS PAQAASPFIP LDELSSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PABIR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 11 nTPM
parathyroid gland: 10 nTPM
placenta: 9.5 nTPM
liver: 9.2 nTPM
breast: 9.1 nTPM
cervix: 9.1 nTPM

Single-cell type

basal keratinocytes: 0.3 nCPM
endometrial secretory cells: 0.3 nCPM
late spermatids: 0.2 nCPM
megakaryocyte-erythroid progenitors: 0.2 nCPM
alveolar cells type 1: 0.1 nCPM
early spermatids: 0.1 nCPM

Immune cell

naive CD4 T-cell: 3.6 nTPM
plasmacytoid DC: 2.6 nTPM
naive B-cell: 2.5 nTPM
myeloid DC: 2.2 nTPM
classical monocyte: 2 nTPM
naive CD8 T-cell: 2 nTPM

Brain region

choroid plexus: 30 nTPM
cerebellum: 15 nTPM
midbrain: 9.2 nTPM
hypothalamus: 9.1 nTPM
hippocampal formation: 9 nTPM
cerebral cortex: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0.49
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

PABIR1/2/3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PABIR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PABIR1 as an antibody target. Whether an autoantibody or antibody against PABIR1 could matter depends on whether native PABIR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PABIR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PABIR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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