Seroatlas · Human Serome Atlas

SPRY2

Protein sprouty homolog 2

Also known as: hSPRY2, SPY2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43597
Gene
SPRY2
Ensembl
ENSG00000136158
Chromosome
13
Canonical length
315 aa
Protein class
Disease related genes, Plasma proteins, Predicted membrane proteins
Subcellular location
Actin filaments,Microtubules

OverviewNCBI Gene

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>O43597|SPRY2
     1  MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT
    61  VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQHSQVH SSARAPLSRS ISTVSSGSRS
   121  STRTSTSSSS SEQRLLGSSF SSGPVADGII RVQPKSELKP GELKPLSKED LGLHAYRCED
   181  CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN
   241  PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC
   301  CKVPTVPPRN FEKPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPRY2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 64 nTPM
  • adipose tissue: 62 nTPM
  • breast: 59 nTPM
  • heart muscle: 46 nTPM
  • blood vessel: 40 nTPM
  • tongue: 39 nTPM

Single-cell type

  • bergmann glia: 134 nCPM
  • epididymal basal cells: 103 nCPM
  • müller glia: 99 nCPM
  • schwann cells: 87 nCPM
  • fibro-adipogenic progenitors: 79 nCPM
  • astrocytes: 79 nCPM

Immune cell

  • NK-cell: 4.1 nTPM
  • eosinophil: 2.1 nTPM
  • myeloid DC: 0.9 nTPM
  • memory CD8 T-cell: 0.8 nTPM
  • memory B-cell: 0.4 nTPM
  • gdT-cell: 0.3 nTPM

Brain region

  • cerebellum: 78 nTPM
  • medulla oblongata: 64 nTPM
  • white matter: 48 nTPM
  • cerebral cortex: 47 nTPM
  • spinal cord: 47 nTPM
  • midbrain: 42 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPRY2.

Disease | AllUniProt

Conditions SPRY2 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.97
gnomAD missense Z
0.97
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPRY2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPRY2 as an antibody target. Whether an autoantibody or antibody against SPRY2 could matter depends on whether native SPRY2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPRY2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPRY2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPRY2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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