Seroatlas · Human Serome Atlas

CTTNBP2NL

CTTNBP2 N-terminal-like protein

Also known as: CT2NL_HUMAN, DKFZp547A023

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2B4
Gene: CTTNBP2NL
Ensembl: ENSG00000143079
Chromosome: 1
Canonical length: 639 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Enables protein phosphatase 2A binding activity. Acts upstream of or within negative regulation of transmembrane transport; negative regulation of transporter activity; and protein dephosphorylation. Located in actin cytoskeleton. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

639 residues, UniProt reviewed canonical sequence.

>Q9P2B4|CTTNBP2NL
     1  MNLEKLSKPE LLTLFSILEG ELEARDLVIE ALKAQHRDTF IEERYGKYNI SDPLMALQRD
    61  FETLKEKNDG EKQPVCTNPL SILKVVMKQC KNMQERMLSQ LAAAESRHRK VILDLEEERQ
   121  RHAQDTAEGD DVTYMLEKER ERLTQQLEFE KSQVKKFEKE QKKLSSQLEE ERSRHKQLSS
   181  MLVLECKKAT NKAAEEGQKA GELSLKLEKE KSRVSKLEEE LAAERKRGLQ TEAQVEKQLS
   241  EFDIEREQLR AKLNREENRT KTLKEEMESL KKIVKDLEAS HQHSSPNEQL KKPVTVSKGT
   301  ATEPLMLMSV FCQTESFPAE RTHGSNIAKM TNTGLPGPAT PAYSYAKTNG HCDPEIQTTR
   361  ELTAGNNVEN QVPPREKSVA LAQEKPVENG GCPVGIETPV PMPSPLSSSG SSLSPSSTAS
   421  SSLTSSPCSS PVLTKRLLGS SASSPGYQSS YQVGINQRFH AARHKFQSQA DQDQQASGLQ
   481  SPPSRDLSPT LIDNSAAKQL ARNTVTQVLS RFTSQQGPIK PVSPNSSPFG TDYRNLANTA
   541  NPRGDTSHSP TPGKVSSPLS PLSPGIKSPT IPRAERGNPP PIPPKKPGLT PSPSATTPLT
   601  KTHSQAASLT TAEDLASSCS SNTVVANGKD VELLLPTSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTTNBP2NL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

placenta: 19 nTPM
esophagus: 18 nTPM
gallbladder: 16 nTPM
colon: 15 nTPM
urinary bladder: 15 nTPM
skin: 14 nTPM

Single-cell type

esophageal apical cells: 377 nCPM
microglia: 346 nCPM
cdc: 243 nCPM
vascular endothelial cells: 193 nCPM
ocular epithelial cells: 192 nCPM
urothelial cells: 181 nCPM

Immune cell

myeloid DC: 8.6 nTPM
plasmacytoid DC: 3.7 nTPM
classical monocyte: 2.6 nTPM
intermediate monocyte: 2.1 nTPM
T-reg: 2 nTPM
non-classical monocyte: 0.4 nTPM

Brain region

medulla oblongata: 26 nTPM
hypothalamus: 26 nTPM
white matter: 25 nTPM
cerebral cortex: 24 nTPM
midbrain: 24 nTPM
pons: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
gnomAD missense Z: 0.83
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of transmembrane transport
protein dephosphorylation
protein localization to actin cytoskeleton
negative regulation of transporter activity

Molecular functions

protein phosphatase 2A binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTTNBP2NL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTTNBP2NL as an antibody target. Whether an autoantibody or antibody against CTTNBP2NL could matter depends on whether native CTTNBP2NL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTTNBP2NL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTTNBP2NL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...