Seroatlas · Human Serome Atlas

GSK3B

Glycogen synthase kinase-3 beta

Also known as: GSK3B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49841
Gene
GSK3B
Ensembl
ENSG00000082701
Chromosome
3
Canonical length
420 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>P49841|GSK3B
     1  MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK
    61  VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG
   121  EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR
   181  DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV
   241  WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
   301  WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF
   361  NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSK3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • retina: 22 nTPM
  • cerebral cortex: 20 nTPM
  • thymus: 19 nTPM
  • heart muscle: 17 nTPM
  • testis: 17 nTPM
  • tongue: 17 nTPM

Single-cell type

  • neutrophils: 761 nCPM
  • neutrophil progenitors: 424 nCPM
  • corticotrophs: 332 nCPM
  • microglia: 332 nCPM
  • ocular epithelial cells: 323 nCPM
  • oligodendrocyte progenitor cells: 313 nCPM

Immune cell

  • neutrophil: 6.8 nTPM
  • eosinophil: 6.3 nTPM
  • non-classical monocyte: 2.2 nTPM
  • classical monocyte: 1.8 nTPM
  • memory CD8 T-cell: 1.7 nTPM
  • intermediate monocyte: 1.6 nTPM

Brain region

  • pons: 84 nTPM
  • cerebellum: 83 nTPM
  • cerebral cortex: 82 nTPM
  • midbrain: 82 nTPM
  • medulla oblongata: 81 nTPM
  • hypothalamus: 78 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GSK3B.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 76 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
2.8
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GSK3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSK3B as an antibody target. Whether an autoantibody or antibody against GSK3B could matter depends on whether native GSK3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSK3B is annotated at the cell surface, where native GSK3B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GSK3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GSK3B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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