Seroatlas · Human Serome Atlas

POLR2C

DNA-directed RNA polymerase II subunit RPB3

Also known as: RPB3, RPB3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P19387
Gene: POLR2C
Ensembl: ENSG00000102978
Chromosome: 16
Canonical length: 275 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>P19387|POLR2C
     1  MPYANQPTVR ITELTDENVK FIIENTDLAV ANSIRRVFIA EVPIIAIDWV QIDANSSVLH
    61  DEFIAHRLGL IPLISDDIVD KLQYSRDCTC EEFCPECSVE FTLDVRCNED QTRHVTSRDL
   121  ISNSPRVIPV TSRNRDNDPN DYVEQDDILI VKLRKGQELR LRAYAKKGFG KEHAKWNPTA
   181  GVAFEYDPDN ALRHTVYPKP EEWPKSEYSE LDEDESQAPY DPNGKPERFY YNVESCGSLR
   241  PETIVLSALS GLKKKLSDLQ TQLSHEIQSD VLTIN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLR2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 82 nTPM
epididymis: 63 nTPM
liver: 58 nTPM
ovary: 58 nTPM
tongue: 57 nTPM
kidney: 56 nTPM

Single-cell type

alveolar cells type 2: 104 nCPM
syncytiotrophoblasts: 104 nCPM
oocytes: 97 nCPM
extravillous trophoblasts: 96 nCPM
migrating cytotrophoblasts: 95 nCPM
cytotrophoblasts: 93 nCPM

Immune cell

neutrophil: 97 nTPM
basophil: 80 nTPM
eosinophil: 71 nTPM
NK-cell: 65 nTPM
naive CD4 T-cell: 61 nTPM
total PBMC: 60 nTPM

Brain region

white matter: 40 nTPM
spinal cord: 37 nTPM
cerebellum: 37 nTPM
hypothalamus: 36 nTPM
pons: 36 nTPM
cerebral cortex: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about POLR2C.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 33 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic non-acquired premature ovarian failure

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 1.86
DepMap mean gene effect: -2.09
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLR2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLR2C as an antibody target. Whether an autoantibody or antibody against POLR2C could matter depends on whether native POLR2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLR2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLR2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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