Seroatlas · Human Serome Atlas

POLR2G

DNA-directed RNA polymerase II subunit RPB7

Also known as: hRPB19, hsRPB7, RPB7, RPB7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62487
Gene: POLR2G
Ensembl: ENSG00000168002
Chromosome: 11
Canonical length: 172 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>P62487|POLR2G
     1  MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT IDNIGAGVIQ
    61  PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE IGPMSCFISR HSIPSEMEFD
   121  PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT RVDKNDIFAI GSLMDDYLGL VS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLR2G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 105 nTPM

Expression across tissuesHPA

Tissue

thymus: 105 nTPM
spinal cord: 102 nTPM
tonsil: 99 nTPM
midbrain: 84 nTPM
basal ganglia: 84 nTPM
amygdala: 84 nTPM

Single-cell type

cytotrophoblasts: 269 nCPM
platelets: 266 nCPM
hofbauer cells: 250 nCPM
decidual stromal cells: 198 nCPM
gastric progenitor cells: 183 nCPM
migrating cytotrophoblasts: 180 nCPM

Immune cell

total PBMC: 231 nTPM
plasmacytoid DC: 185 nTPM
non-classical monocyte: 176 nTPM
myeloid DC: 175 nTPM
basophil: 171 nTPM
eosinophil: 165 nTPM

Brain region

white matter: 60 nTPM
medulla oblongata: 51 nTPM
spinal cord: 46 nTPM
cerebellum: 42 nTPM
hypothalamus: 40 nTPM
thalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: 2.09
DepMap mean gene effect: -1.62
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLR2G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLR2G as an antibody target. Whether an autoantibody or antibody against POLR2G could matter depends on whether native POLR2G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLR2G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLR2G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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