Seroatlas · Human Serome Atlas

MED18

Mediator of RNA polymerase II transcription subunit 18

Also known as: FLJ20045, MED18_HUMAN, p28b, SRB5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUE0
Gene: MED18
Ensembl: ENSG00000130772
Chromosome: 1
Canonical length: 208 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q9BUE0|MED18
     1  MEAPPVTMMP VTGGTINMME YLLQGSVLDH SLESLIHRLR GLCDNMEPET FLDHEMVFLL
    61  KGQQASPFVL RARRSMDRAG APWHLRYLGQ PEMGDKNRHA LVRNCVDIAT SENLTDFLME
   121  MGFRMDHEFV AKGHLFRKGI MKIMVYKIFR ILVPGNTDST EALSLSYLVE LSVVAPAGQD
   181  MVSDDMKNFA EQLKPLVHLE KIDPKRLM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MED18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

liver: 15 nTPM
spleen: 9.8 nTPM
esophagus: 9.6 nTPM
colon: 8.9 nTPM
small intestine: 8.9 nTPM
skeletal muscle: 8.8 nTPM

Single-cell type

loop of henle epithelial cells: 2.8 nCPM
podocytes: 2.8 nCPM
renal collecting duct principal cells: 2.8 nCPM
gastric progenitor cells: 2.6 nCPM
proximal tubule cells: 2.5 nCPM
microglia: 2.4 nCPM

Immune cell

eosinophil: 5.1 nTPM
neutrophil: 4.9 nTPM
non-classical monocyte: 4.2 nTPM
plasmacytoid DC: 3.9 nTPM
memory B-cell: 3.7 nTPM
T-reg: 3.7 nTPM

Brain region

choroid plexus: 5.4 nTPM
thalamus: 4.7 nTPM
hypothalamus: 4.5 nTPM
white matter: 4.5 nTPM
cerebellum: 4.4 nTPM
medulla oblongata: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 1.05
DepMap mean gene effect: -1
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription coregulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Mediator complex, subunit Med18
Med18 protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MED18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MED18 as an antibody target. Whether an autoantibody or antibody against MED18 could matter depends on whether native MED18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MED18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MED18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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