Seroatlas · Human Serome Atlas

RPAP1

RNA polymerase II-associated protein 1

Also known as: DKFZP727M111, FLJ12732, KIAA1403, MGC858, RPAP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWH6
Gene: RPAP1
Ensembl: ENSG00000103932
Chromosome: 15
Canonical length: 1393 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

1393 residues, UniProt reviewed canonical sequence.

>Q9BWH6|RPAP1
     1  MLSRPKPGES EVDLLHFQSQ FLAAGAAPAV QLVKKGNRGG GDANSDRPPL QDHRDVVMLD
    61  NLPDLPPALV PSPPKRARPS PGHCLPEDED PEERLRRHDQ HITAVLTKII ERDTSSVAVN
   121  LPVPSGVAFP AVFLRSRDTQ GKSATSGKRS IFAQEIAARR IAEAKGPSVG EVVPNVGPPE
   181  GAVTCETPTP RNQGCQLPGS SHSFQGPNLV TGKGLRDQEA EQEAQTIHEE NIARLQAMAP
   241  EEILQEQQRL LAQLDPSLVA FLRSHSHTQE QTGETASEEQ RPGGPSANVT KEEPLMSAFA
   301  SEPRKRDKLE PEAPALALPV TPQKEWLHMD TVELEKLHWT QDLPPVRRQQ TQERMQARFS
   361  LQGELLAPDV DLPTHLGLHH HGEEAERAGY SLQELFHLTR SQVSQQRALA LHVLAQVISR
   421  AQAGEFGDRL AGSVLSLLLD AGFLFLLRFS LDDRVDGVIA TAIRALRALL VAPGDEELLD
   481  STFSWYHGAL TFPLMPSQED KEDEDEDEEC PAGKAKRKSP EEESRPPPDL ARHDVIKGLL
   541  ATSLLPRLRY VLEVTYPGPA VVLDILAVLI RLARHSLESA TRVLECPRLI ETIVREFLPT
   601  SWSPVGAGPT PSLYKVPCAT AMKLLRVLAS AGRNIAARLL SSFDLRSRLC RIIAEAPQEL
   661  ALPPEEAEML STEALRLWAV AASYGQGGYL YRELYPVLMR ALQVVPRELS THPPQPLSMQ
   721  RIASLLTLLT QLTLAAGSTP AETISDSAEA SLSATPSLVT WTQVSGLQPL VEPCLRQTLK
   781  LLSRPEMWRA VGPVPVACLL FLGAYYQAWS QQPSSCPEDW LQDMQRLSEE LLLPLLSQPT
   841  LGSLWDSLRH CSLLCNPLSC VPALEAPPSL VSLGCSGGCP RLSLAGSASP FPFLTALLSL
   901  LNTLAQIHKG LCGQLAAILA APGLQNYFLQ CVAPGAAPHL TPFSAWALRH EYHLQYLALA
   961  LAQKAAALQP LPATHAALYH GMALALLSRL LPGSEYLTHE LLLSCVFRLE FLPERTSGGP
  1021  EAADFSDQLS LGSSRVPRCG QGTLLAQACQ DLPSIRNCYL THCSPARASL LASQALHRGE
  1081  LQRVPTLLLP MPTEPLLPTD WPFLPLIRLY HRASDTPSGL SPTDTMGTAM RVLQWVLVLE
  1141  SWRPQALWAV PPAARLARLM CVFLVDSELF RESPVQHLVA ALLAQLCQPQ VLPNLNLDCR
  1201  LPGLTSFPDL YANFLDHFEA VSFGDHLFGA LVLLPLQRRF SVTLRLALFG EHVGALRALS
  1261  LPLTQLPVSL ECYTVPPEDN LALLQLYFRT LVTGALRPRW CPVLYAVAVA HVNSFIFSQD
  1321  PQSSDEVKAA RRSMLQKTWL LADEGLRQHL LHYKLPNSTL PEGFELYSQL PPLRQHYLQR
  1381  LTSTVLQNGV SET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 17 nTPM
tongue: 11 nTPM
esophagus: 7.6 nTPM
parathyroid gland: 6.8 nTPM
urinary bladder: 6.8 nTPM
lymph node: 6.7 nTPM

Single-cell type

retinal horizontal cells: 26 nCPM
myonuclei: 24 nCPM
retinal ganglion cells: 23 nCPM
adrenal cortex cells: 20 nCPM
thymic myoid cells: 20 nCPM
early primary spermatocytes: 19 nCPM

Immune cell

gdT-cell: 4.6 nTPM
non-classical monocyte: 4.4 nTPM
MAIT T-cell: 4 nTPM
naive CD4 T-cell: 3.7 nTPM
naive CD8 T-cell: 3.4 nTPM
naive B-cell: 3.3 nTPM

Brain region

white matter: 16 nTPM
basal ganglia: 15 nTPM
cerebral cortex: 15 nTPM
medulla oblongata: 15 nTPM
midbrain: 15 nTPM
thalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0
gnomAD missense Z: 1.54
DepMap mean gene effect: -1.72
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RPAP1, C-terminal
RPAP1, N-terminal
RNA polymerase II-associated protein RPAP1/Rba50
RPAP1/MINIYO-like, TPR repeats
RPAP1-like, C-terminal
RPAP1-like, N-terminal
RNA polymerase II-associated protein 1, TPR repeats

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPAP1 as an antibody target. Whether an autoantibody or antibody against RPAP1 could matter depends on whether native RPAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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