Seroatlas · Human Serome Atlas

MED10

Mediator of RNA polymerase II transcription subunit 10

Also known as: L6, MED10_HUMAN, MGC5309, NUT2, TRG20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTT4
Gene: MED10
Ensembl: ENSG00000133398
Chromosome: 5
Canonical length: 135 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

Canonical amino-acid sequenceUniProt

135 residues, UniProt reviewed canonical sequence.

>Q9BTT4|MED10
     1  MAEKFDHLEE HLEKFVENIR QLGIIVSDFQ PSSQAGLNQK LNFIVTGLQD IDKCRQQLHD
    61  ITVPLEVFEY IDQGRNPQLY TKECLERALA KNEQVKGKID TMKKFKSLLI QELSKVFPED
   121  MAKYRSIRGE DHPPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MED10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 52 nTPM
cerebral cortex: 42 nTPM
hypothalamus: 40 nTPM
hippocampal formation: 38 nTPM
spinal cord: 38 nTPM
amygdala: 38 nTPM

Single-cell type

oocytes: 143 nCPM
esophageal apical cells: 131 nCPM
epididymal principal cells: 125 nCPM
esophageal basal cells: 110 nCPM
esophageal suprabasal cells: 105 nCPM
breast lactating cells: 104 nCPM

Immune cell

basophil: 128 nTPM
total PBMC: 109 nTPM
naive CD4 T-cell: 102 nTPM
memory B-cell: 99 nTPM
eosinophil: 95 nTPM
memory CD4 T-cell: 94 nTPM

Brain region

hypothalamus: 37 nTPM
pons: 35 nTPM
hippocampal formation: 32 nTPM
white matter: 31 nTPM
cerebral cortex: 30 nTPM
midbrain: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0.05
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.55
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Mediator complex, subunit Med10
Transcription factor subunit Med10 of Mediator complex

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MED10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MED10 as an antibody target. Whether an autoantibody or antibody against MED10 could matter depends on whether native MED10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MED10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MED10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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