Seroatlas · Human Serome Atlas

RPAP2

Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

Also known as: C1orf82, FLJ13150, RPAP2_HUMAN, Rtr1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IXW5
Gene
RPAP2
Ensembl
ENSG00000122484
Chromosome
1
Canonical length
612 aa
Protein class
Enzymes, Predicted membrane proteins
Subcellular location
Nucleoli,Primary cilium,Cytosol

OverviewNCBI Gene

Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in PERK-mediated unfolded protein response and snRNA transcription. Located in cilium; cytosol; and nucleolus. Part of transcription preinitiation complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

612 residues, UniProt reviewed canonical sequence.

>Q8IXW5|RPAP2
     1  MADFAGPSSA GRKAGAPRCS RKAAGTKQTS TLKQEDASKR KAELEAAVRK KIEFERKALH
    61  IVEQLLEENI TEEFLMECGR FITPAHYSDV VDERSIVKLC GYPLCQKKLG IVPKQKYKIS
   121  TKTNKVYDIT ERKSFCSNFC YQASKFFEAQ IPKTPVWVRE EERHPDFQLL KEEQSGHSGE
   181  EVQLCSKAIK TSDIDNPSHF EKQYESSSSS THSDSSSDNE QDFVSSILPG NRPNSTNIRP
   241  QLHQKSIMKK KAGHKANSKH KDKEQTVVDV TEQLGDCKLD SQEKDATCEL PLQKVNTQSS
   301  SNSTLPERLK ASENSESEYS RSEITLVGIS KKSAEHFKRK FAKSNQVSRS VSSSVQVCPE
   361  VGKRNLLKVL KETLIEWKTE ETLRFLYGQN YASVCLKPEA SLVKEELDED DIISDPDSHF
   421  PAWRESQNSL DESLPFRGSG TAIKPLPSYE NLKKETEKLN LRIREFYRGR YVLGEETTKS
   481  QDSEEHDSTF PLIDSSSQNQ IRKRIVLEKL SKVLPGLLVP LQITLGDIYT QLKNLVRTFR
   541  LTNRNIIHKP AEWTLIAMVL LSLLTPILGI QKHSQEGMVF TRFLDTLLEE LHLKNEDLES
   601  LTIIFRTSCL PE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
8 nTPM

Expression across tissuesHPA

Tissue

  • retina: 8 nTPM
  • cerebellum: 6.4 nTPM
  • bone marrow: 3.2 nTPM
  • epididymis: 2.8 nTPM
  • liver: 2.7 nTPM
  • skeletal muscle: 2.7 nTPM

Single-cell type

  • myonuclei: 278 nCPM
  • rod photoreceptor cells: 202 nCPM
  • choroid plexus epithelial cells: 196 nCPM
  • adipocytes: 176 nCPM
  • thymocytes: 169 nCPM
  • retinal ganglion cells: 166 nCPM

Immune cell

  • basophil: 1.7 nTPM
  • MAIT T-cell: 1.4 nTPM
  • gdT-cell: 1.2 nTPM
  • naive B-cell: 1.2 nTPM
  • neutrophil: 1.2 nTPM
  • NK-cell: 1.2 nTPM

Brain region

  • cerebellum: 63 nTPM
  • cerebral cortex: 56 nTPM
  • white matter: 54 nTPM
  • basal ganglia: 46 nTPM
  • amygdala: 46 nTPM
  • hippocampal formation: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
0.74
DepMap mean gene effect
-0.95
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Rtr1/RPAP2 domain
  • Rtr1/RPAP2 domain superfamily
  • Rtr1/RPAP2
  • Rtr1/RPAP2 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPAP2 as an antibody target. Whether an autoantibody or antibody against RPAP2 could matter depends on whether native RPAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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