RPRD1B
Regulation of nuclear pre-mRNA domain-containing protein 1B
Also known as: C20orf77, CREPT, dJ1057B20.2, DKFZp434P0735, FLJ44520, K-H, Kub5-Hera, NET60, RPR1B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NQG5
- Gene
- RPRD1B
- Ensembl
- ENSG00000101413
- Chromosome
- 20
- Canonical length
- 326 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in several processes, including RNA polymerase II promoter clearance; positive regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription preinitiation complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
326 residues, UniProt reviewed canonical sequence.
>Q9NQG5|RPRD1B
1 MSSFSESALE KKLSELSNSQ QSVQTLSLWL IHHRKHAGPI VSVWHRELRK AKSNRKLTFL
61 YLANDVIQNS KRKGPEFTRE FESVLVDAFS HVAREADEGC KKPLERLLNI WQERSVYGGE
121 FIQQLKLSME DSKSPPPKAT EEKKSLKRTF QQIQEEEDDD YPGSYSPQDP SAGPLLTEEL
181 IKALQDLENA ASGDATVRQK IASLPQEVQD VSLLEKITDK EAAERLSKTV DEACLLLAEY
241 NGRLAAELED RRQLARMLVE YTQNQKDVLS EKEKKLEEYK QKLARVTQVR KELKSHIQSL
301 PDLSLLPNVT GGLAPLPSAG DLFSTDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RPRD1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 74 nTPM
Expression across tissuesHPA
Tissue
- liver: 74 nTPM
- skeletal muscle: 34 nTPM
- bone marrow: 33 nTPM
- tonsil: 28 nTPM
- tongue: 24 nTPM
- heart muscle: 22 nTPM
Single-cell type
- hepatocytes: 94 nCPM
- erythrocyte progenitors: 83 nCPM
- myonuclei: 82 nCPM
- pituicytes/fscs: 73 nCPM
- neutrophil progenitors: 73 nCPM
- cardiomyocytes: 69 nCPM
Immune cell
- non-classical monocyte: 9 nTPM
- intermediate monocyte: 6.6 nTPM
- myeloid DC: 6 nTPM
- classical monocyte: 5.8 nTPM
- eosinophil: 5.8 nTPM
- MAIT T-cell: 5.7 nTPM
Brain region
- white matter: 39 nTPM
- cerebellum: 37 nTPM
- hypothalamus: 36 nTPM
- basal ganglia: 34 nTPM
- medulla oblongata: 33 nTPM
- thalamus: 32 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.6
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 2.1
- DepMap mean gene effect
- -0.42
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- mRNA 3'-end processing
- positive regulation of cell population proliferation
- positive regulation of transcription by RNA polymerase II
- regulation of cell cycle process
- RNA polymerase II promoter clearance
Molecular functions
- identical protein binding
- RNA polymerase II C-terminal domain binding
- RNA polymerase II complex binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RPRD1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RPRD1B as an antibody target. Whether an autoantibody or antibody against RPRD1B could matter depends on whether native RPRD1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RPRD1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RPRD1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...