Seroatlas · Human Serome Atlas

MED11

Mediator of RNA polymerase II transcription subunit 11

Also known as: HSPC296, MED11_HUMAN, MGC88387

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P086
Gene
MED11
Ensembl
ENSG00000161920
Chromosome
17
Canonical length
117 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>Q9P086|MED11
     1  MATYSLANER LRALEDIERE IGAILQNAGT VILELSKEKT NERLLDRQAA AFTASVQHVE
    61  AELSAQIRYL TQVATGQPHE GSSYSSRKDC QMALKRVDYA RLKLSDVART CEQMLEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MED11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 40 nTPM
  • skeletal muscle: 38 nTPM
  • liver: 37 nTPM
  • kidney: 36 nTPM
  • choroid plexus: 35 nTPM
  • parathyroid gland: 33 nTPM

Single-cell type

  • esophageal suprabasal cells: 77 nCPM
  • early primary spermatocytes: 74 nCPM
  • parietal cells: 71 nCPM
  • tuft cells: 69 nCPM
  • esophageal basal cells: 67 nCPM
  • enterocytes: 60 nCPM

Immune cell

  • neutrophil: 137 nTPM
  • eosinophil: 80 nTPM
  • non-classical monocyte: 68 nTPM
  • memory B-cell: 63 nTPM
  • naive B-cell: 62 nTPM
  • naive CD8 T-cell: 53 nTPM

Brain region

  • white matter: 33 nTPM
  • cerebellum: 28 nTPM
  • medulla oblongata: 27 nTPM
  • basal ganglia: 26 nTPM
  • thalamus: 25 nTPM
  • midbrain: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MED11.

Disease | AllUniProt

Conditions MED11 is implicated in, by any mechanism.

  • Neurodegeneration with developmental delay, early respiratory failure, myoclonic seizures, and brain abnormalities (NDDRSB) MIM:620327

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 23 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodegeneration with developmental delay, early respiratory failure, myoclonic seizures, and brain abnormalities

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0
gnomAD missense Z
0.65
DepMap mean gene effect
-1.83
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Mediator complex, subunit Med11
  • Mediator complex protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MED11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MED11 as an antibody target. Whether an autoantibody or antibody against MED11 could matter depends on whether native MED11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MED11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MED11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MED11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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