Seroatlas · Human Serome Atlas

COMMD10

COMM domain-containing protein 10

Also known as: COMDA_HUMAN, PTD002

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6G5
Gene: COMMD10
Ensembl: ENSG00000145781
Chromosome: 5
Canonical length: 202 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>Q9Y6G5|COMMD10
     1  MAVPAALILR ESPSMKKAVS LINAIDTGRF PRLLTRILQK LHLKAESSFS EEEEEKLQAA
    61  FSLEKQDLHL VLETISFILE QAVYHNVKPA ALQQQLENIH LRQDKAEAFV NTWSSMGQET
   121  VEKFRQRILA PCKLETVGWQ LNLQMAHSAQ AKLKSPQAVL QLGVNNEDSK SLEKVLVEFS
   181  HKELFDFYNK LETIQAQLDS LT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COMMD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

kidney: 33 nTPM
epididymis: 30 nTPM
heart muscle: 29 nTPM
salivary gland: 29 nTPM
thyroid gland: 26 nTPM
parathyroid gland: 24 nTPM

Single-cell type

myonuclei: 492 nCPM
pdcs: 481 nCPM
microglia: 365 nCPM
cardiomyocytes: 340 nCPM
neutrophil progenitors: 321 nCPM
corticotrophs: 320 nCPM

Immune cell

myeloid DC: 33 nTPM
non-classical monocyte: 31 nTPM
intermediate monocyte: 30 nTPM
plasmacytoid DC: 25 nTPM
classical monocyte: 25 nTPM
NK-cell: 23 nTPM

Brain region

white matter: 18 nTPM
choroid plexus: 17 nTPM
spinal cord: 15 nTPM
thalamus: 15 nTPM
hypothalamus: 15 nTPM
midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -0.88
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

COMM domain
COMM domain
COMMD2-7/10, HN domain
COMM domain-containing protein 10

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COMMD10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COMMD10 as an antibody target. Whether an autoantibody or antibody against COMMD10 could matter depends on whether native COMMD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COMMD10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COMMD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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