Seroatlas · Human Serome Atlas

COMMD5

COMM domain-containing protein 5

Also known as: COMD5_HUMAN, FLJ13008, HCaRG, HT002

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZQ3
Gene: COMMD5
Ensembl: ENSG00000170619
Chromosome: 8
Canonical length: 224 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in proximal tubule morphogenesis. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q9GZQ3|COMMD5
     1  MSAVGAATPY LHHPGDSHSG RVSFLGAQLP PEVAAMARLL GDLDRSTFRK LLKFVVSSLQ
    61  GEDCREAVQR LGVSANLPEE QLGALLAGMH TLLQQALRLP PTSLKPDTFR DQLQELCIPQ
   121  DLVGDLASVV FGSQRPLLDS VAQQQGAWLP HVADFRWRVD VAISTSALAR SLQPSVLMQL
   181  KLSDGSAYRF EVPTAKFQEL RYSVALVLKE MADLEKRCER RLQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COMMD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

liver: 22 nTPM
adrenal gland: 22 nTPM
spleen: 21 nTPM
bone marrow: 20 nTPM
esophagus: 19 nTPM
spinal cord: 19 nTPM

Single-cell type

esophageal apical cells: 144 nCPM
cardiomyocytes: 95 nCPM
hofbauer cells: 94 nCPM
epicardial cells: 64 nCPM
megakaryocytes: 50 nCPM
esophageal suprabasal cells: 45 nCPM

Immune cell

classical monocyte: 84 nTPM
eosinophil: 77 nTPM
myeloid DC: 74 nTPM
intermediate monocyte: 73 nTPM
T-reg: 71 nTPM
total PBMC: 70 nTPM

Brain region

white matter: 23 nTPM
medulla oblongata: 21 nTPM
cerebellum: 21 nTPM
cerebral cortex: 20 nTPM
spinal cord: 20 nTPM
thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

COMM domain
COMM domain
COMMD2-7/10, HN domain
COMM domain-containing protein 5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COMMD5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COMMD5 as an antibody target. Whether an autoantibody or antibody against COMMD5 could matter depends on whether native COMMD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COMMD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COMMD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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