Seroatlas · Human Serome Atlas

PPP2R5B

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

Also known as: 2A5B_HUMAN, B56B, B56beta, FLJ35411, PR61B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15173
Gene
PPP2R5B
Ensembl
ENSG00000068971
Chromosome
11
Canonical length
497 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

497 residues, UniProt reviewed canonical sequence.

>Q15173|PPP2R5B
     1  METKLPPAST PTSPSSPGLS PVPPPDKVDG FSRRSLRRAR PRRSHSSSQF RYQSNQQELT
    61  PLPLLKDVPA SELHELLSRK LAQCGVMFDF LDCVADLKGK EVKRAALNEL VECVGSTRGV
   121  LIEPVYPDII RMISVNIFRT LPPSENPEFD PEEDEPNLEP SWPHLQLVYE FFLRFLESPD
   181  FQPSVAKRYV DQKFVLMLLE LFDSEDPRER EYLKTILHRV YGKFLGLRAY IRKQCNHIFL
   241  RFIYEFEHFN GVAELLEILG SIINGFALPL KTEHKQFLVR VLIPLHSVKS LSVFHAQLAY
   301  CVVQFLEKDA TLTEHVIRGL LKYWPKTCTQ KEVMFLGEME EILDVIEPSQ FVKIQEPLFK
   361  QVARCVSSPH FQVAERALYF WNNEYILSLI EDNCHTVLPA VFGTLYQVSK EHWNQTIVSL
   421  IYNVLKTFME MNGKLFDELT ASYKLEKQQE QQKAQERQEL WQGLEELRLR RLQGTQGAKE
   481  APLQRLTPQV AASGGQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP2R5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
113 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 113 nTPM
  • basal ganglia: 65 nTPM
  • cerebral cortex: 63 nTPM
  • hypothalamus: 52 nTPM
  • midbrain: 41 nTPM
  • hippocampal formation: 41 nTPM

Single-cell type

  • retinal amacrine cells: 39 nCPM
  • ocular epithelial cells: 31 nCPM
  • brain excitatory neurons: 31 nCPM
  • brain inhibitory neurons: 31 nCPM
  • other brain neurons: 28 nCPM
  • retinal bipolar cells: 26 nCPM

Immune cell

  • eosinophil: 8.9 nTPM
  • non-classical monocyte: 1.3 nTPM
  • intermediate monocyte: 1 nTPM
  • basophil: 0.9 nTPM
  • naive B-cell: 0.9 nTPM
  • T-reg: 0.8 nTPM

Brain region

  • cerebral cortex: 97 nTPM
  • medulla oblongata: 93 nTPM
  • pons: 93 nTPM
  • white matter: 88 nTPM
  • cerebellum: 86 nTPM
  • thalamus: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
2.46
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP2R5B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP2R5B as an antibody target. Whether an autoantibody or antibody against PPP2R5B could matter depends on whether native PPP2R5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP2R5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP2R5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP2R5B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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