Seroatlas · Human Serome Atlas

CCNB2

G2/mitotic-specific cyclin-B2

Also known as: CCNB2_HUMAN, HsT17299

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95067
Gene
CCNB2
Ensembl
ENSG00000157456
Chromosome
15
Canonical length
398 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>O95067|CCNB2
     1  MALLRRPTVS SDLENIDTGV NSKVKSHVTI RRTVLEEIGN RVTTRAAQVA KKAQNTKVPV
    61  QPTKTTNVNK QLKPTASVKP VQMEKLAPKG PSPTPEDVSM KEENLCQAFS DALLCKIEDI
   121  DNEDWENPQL CSDYVKDIYQ YLRQLEVLQS INPHFLDGRD INGRMRAILV DWLVQVHSKF
   181  RLLQETLYMC VGIMDRFLQV QPVSRKKLQL VGITALLLAS KYEEMFSPNI EDFVYITDNA
   241  YTSSQIREME TLILKELKFE LGRPLPLHFL RRASKAGEVD VEQHTLAKYL MELTLIDYDM
   301  VHYHPSKVAA AASCLSQKVL GQGKWNLKQQ YYTGYTENEV LEVMQHMAKN VVKVNENLTK
   361  FIAIKNKYAS SKLLKISMIP QLNSKAVKDL ASPLIGRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 70 nTPM
  • thymus: 68 nTPM
  • testis: 65 nTPM
  • tonsil: 41 nTPM
  • lymph node: 31 nTPM
  • rectum: 16 nTPM

Single-cell type

  • late primary spermatocytes: 553 nCPM
  • oocytes: 336 nCPM
  • early spermatids: 108 nCPM
  • erythrocyte progenitors: 94 nCPM
  • extravillous trophoblasts: 79 nCPM
  • monocyte progenitors: 66 nCPM

Immune cell

  • T-reg: 23 nTPM
  • memory CD8 T-cell: 5 nTPM
  • memory CD4 T-cell: 4.7 nTPM
  • NK-cell: 3.7 nTPM
  • myeloid DC: 3 nTPM
  • memory B-cell: 2.1 nTPM

Brain region

  • white matter: 5.4 nTPM
  • medulla oblongata: 3.9 nTPM
  • choroid plexus: 3.5 nTPM
  • thalamus: 3.5 nTPM
  • basal ganglia: 3.4 nTPM
  • midbrain: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0
gnomAD missense Z
0.07
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNB2 as an antibody target. Whether an autoantibody or antibody against CCNB2 could matter depends on whether native CCNB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCNB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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