Seroatlas · Human Serome Atlas

PIM1

Serine/threonine-protein kinase pim-1

Also known as: PIM, PIM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P11309
Gene
PIM1
Ensembl
ENSG00000137193
Chromosome
6
Canonical length
313 aa
Protein class
Cancer-related genes, Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>P11309|PIM1
     1  MLLSKINSLA HLRAAPCNDL HATKLAPGKE KEPLESQYQV GPLLGSGGFG SVYSGIRVSD
    61  NLPVAIKHVE KDRISDWGEL PNGTRVPMEV VLLKKVSSGF SGVIRLLDWF ERPDSFVLIL
   121  ERPEPVQDLF DFITERGALQ EELARSFFWQ VLEAVRHCHN CGVLHRDIKD ENILIDLNRG
   181  ELKLIDFGSG ALLKDTVYTD FDGTRVYSPP EWIRYHRYHG RSAAVWSLGI LLYDMVCGDI
   241  PFEHDEEIIR GQVFFRQRVS SECQHLIRWC LALRPSDRPT FEEIQNHPWM QDVLLPQETA
   301  EIHLHSLSPG PSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
207 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 207 nTPM
  • esophagus: 191 nTPM
  • adipose tissue: 142 nTPM
  • vagina: 107 nTPM
  • skin: 103 nTPM
  • urinary bladder: 95 nTPM

Single-cell type

  • esophageal apical cells: 1,769 nCPM
  • urothelial cells: 385 nCPM
  • decidual stromal cells: 302 nCPM
  • esophageal suprabasal cells: 221 nCPM
  • suprabasal keratinocytes: 205 nCPM
  • erythrocytes: 205 nCPM

Immune cell

  • basophil: 323 nTPM
  • eosinophil: 114 nTPM
  • MAIT T-cell: 78 nTPM
  • neutrophil: 62 nTPM
  • gdT-cell: 60 nTPM
  • memory CD8 T-cell: 54 nTPM

Brain region

  • medulla oblongata: 23 nTPM
  • pons: 18 nTPM
  • spinal cord: 18 nTPM
  • midbrain: 17 nTPM
  • white matter: 17 nTPM
  • hypothalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.85
gnomAD missense Z
1.96
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIM1 as an antibody target. Whether an autoantibody or antibody against PIM1 could matter depends on whether native PIM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIM1 is annotated at the cell surface, where native PIM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PIM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PIM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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