Seroatlas · Human Serome Atlas

YWHAQ

14-3-3 protein theta

Also known as: 14-3-3, 1433T_HUMAN, HS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P27348
Gene: YWHAQ
Ensembl: ENSG00000134308
Chromosome: 2
Canonical length: 245 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>P27348|YWHAQ
     1  MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN VVGGRRSAWR
    61  VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL LDKYLIANAT NPESKVFYLK
   121  MKGDYFRYLA EVACGDDRKQ TIDNSQGAYQ EAFDISKKEM QPTHPIRLGL ALNFSVFYYE
   181  ILNNPELACT LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA
   241  EGAEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YWHAQ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 259 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 259 nTPM
spinal cord: 235 nTPM
midbrain: 229 nTPM
hypothalamus: 229 nTPM
cerebral cortex: 226 nTPM
amygdala: 225 nTPM

Single-cell type

extravillous trophoblasts: 724 nCPM
esophageal apical cells: 617 nCPM
late primary spermatocytes: 614 nCPM
esophageal suprabasal cells: 528 nCPM
late spermatids: 526 nCPM
esophageal basal cells: 509 nCPM

Immune cell

total PBMC: 344 nTPM
MAIT T-cell: 256 nTPM
NK-cell: 253 nTPM
memory CD8 T-cell: 223 nTPM
T-reg: 209 nTPM
gdT-cell: 208 nTPM

Brain region

white matter: 411 nTPM
hypothalamus: 319 nTPM
basal ganglia: 296 nTPM
medulla oblongata: 294 nTPM
cerebellum: 290 nTPM
pons: 285 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.7
gnomAD missense Z: 1.67
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YWHAQ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YWHAQ as an antibody target. Whether an autoantibody or antibody against YWHAQ could matter depends on whether native YWHAQ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YWHAQ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YWHAQ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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