Seroatlas · Human Serome Atlas

CCND2

G1/S-specific cyclin-D2

Also known as: CCND2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P30279
Gene
CCND2
Ensembl
ENSG00000118971
Chromosome
12
Canonical length
289 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>P30279|CCND2
     1  MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD IQPYMRRMVA
    61  TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL LGAVCMFLAS KLKETSPLTA
   121  EKLCIYTDNS IKPQELLEWE LVVLGKLKWN LAAVTPHDFI EHILRKLPQQ REKLSLIRKH
   181  AQTFIALCAT DFKFAMYPPS MIATGSVGAA ICGLQQDEEV SSLTCDALTE LLAKITNTDV
   241  DCLKACQEQI EAVLLNSLQQ YRQDQRDGSK SEDELDQAST PTDVRDIDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCND2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 28 nTPM
  • bone marrow: 19 nTPM
  • adrenal gland: 17 nTPM
  • duodenum: 16 nTPM
  • pancreas: 15 nTPM
  • placenta: 12 nTPM

Single-cell type

  • plasma cells: 53 nCPM
  • müller glia: 48 nCPM
  • megakaryocyte-erythroid progenitors: 42 nCPM
  • smooth muscle cells: 40 nCPM
  • epididymal basal cells: 40 nCPM
  • megakaryocyte progenitors: 31 nCPM

Immune cell

  • MAIT T-cell: 17 nTPM
  • memory CD4 T-cell: 16 nTPM
  • memory CD8 T-cell: 14 nTPM
  • T-reg: 14 nTPM
  • naive CD8 T-cell: 12 nTPM
  • gdT-cell: 11 nTPM

Brain region

  • cerebral cortex: 85 nTPM
  • basal ganglia: 79 nTPM
  • medulla oblongata: 74 nTPM
  • spinal cord: 73 nTPM
  • hippocampal formation: 72 nTPM
  • amygdala: 63 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCND2.

Disease | AllUniProt

Conditions CCND2 is implicated in, by any mechanism.

  • Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3) MIM:615938

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 174 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
0.99
gnomAD missense Z
2.13
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCND2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCND2 as an antibody target. Whether an autoantibody or antibody against CCND2 could matter depends on whether native CCND2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCND2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCND2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCND2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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