Seroatlas · Human Serome Atlas

CCND1

G1/S-specific cyclin-D1

Also known as: BCL1, CCND1_HUMAN, D11S287E, PRAD1, U21B31

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P24385
Gene
CCND1
Ensembl
ENSG00000110092
Chromosome
11
Canonical length
295 aa
Protein class
Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>P24385|CCND1
     1  MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EVLPSMRKIV
    61  ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT
   121  AEKLCIYTDN SIRPEELLQM ELLLVNKLKW NLAAMTPHDF IEHFLSKMPE AEENKQIIRK
   181  HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP NNFLSYYRLT RFLSRVIKCD
   241  PDCLRACQEQ IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
114 nTPM

Expression across tissuesHPA

Tissue

  • skin: 114 nTPM
  • liver: 100 nTPM
  • pancreas: 82 nTPM
  • parathyroid gland: 78 nTPM
  • esophagus: 70 nTPM
  • heart muscle: 61 nTPM

Single-cell type

  • alveolar cells type 1: 612 nCPM
  • epididymal efferent duct absorptive cells: 586 nCPM
  • pancreatic duct cells: 538 nCPM
  • fallopian secretory cells: 396 nCPM
  • esophageal suprabasal cells: 337 nCPM
  • ocular epithelial cells: 337 nCPM

Immune cell

  • myeloid DC: 1.1 nTPM
  • memory B-cell: 0.9 nTPM
  • naive B-cell: 0.7 nTPM
  • basophil: 0.2 nTPM
  • gdT-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM

Brain region

  • choroid plexus: 71 nTPM
  • white matter: 50 nTPM
  • thalamus: 46 nTPM
  • medulla oblongata: 38 nTPM
  • pons: 36 nTPM
  • spinal cord: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCND1.

Disease | AllUniProt

Conditions CCND1 is implicated in, by any mechanism.

Disease | ImmuneIEDB

Conditions an epitope on CCND1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.89
gnomAD missense Z
1.42
DepMap mean gene effect
-0.98
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCND1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCND1 as an antibody target. Whether an autoantibody or antibody against CCND1 could matter depends on whether native CCND1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCND1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCND1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCND1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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