Seroatlas · Human Serome Atlas

CCNB1

G2/mitotic-specific cyclin-B1

Also known as: CCNB, CCNB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P14635
Gene
CCNB1
Ensembl
ENSG00000134057
Chromosome
5
Canonical length
433 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>P14635|CCNB1
     1  MALRVTRNSK INAENKAKIN MAGAKRVPTA PAATSKPGLR PRTALGDIGN KVSEQLQAKM
    61  PMKKEAKPSA TGKVIDKKLP KPLEKVPMLV PVPVSEPVPE PEPEPEPEPV KEEKLSPEPI
   121  LVDTASPSPM ETSGCAPAEE DLCQAFSDVI LAVNDVDAED GADPNLCSEY VKDIYAYLRQ
   181  LEEEQAVRPK YLLGREVTGN MRAILIDWLV QVQMKFRLLQ ETMYMTVSII DRFMQNNCVP
   241  KKMLQLVGVT AMFIASKYEE MYPPEIGDFA FVTDNTYTKH QIRQMEMKIL RALNFGLGRP
   301  LPLHFLRRAS KIGEVDVEQH TLAKYLMELT MLDYDMVHFP PSQIAAGAFC LALKILDNGE
   361  WTPTLQHYLS YTEESLLPVM QHLAKNVVMV NQGLTKHMTV KNKYATSKHA KISTLPQLNS
   421  ALVQDLAKAV AKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 71 nTPM
  • tonsil: 63 nTPM
  • lymph node: 51 nTPM
  • bone marrow: 50 nTPM
  • esophagus: 35 nTPM
  • testis: 31 nTPM

Single-cell type

  • extravillous trophoblasts: 893 nCPM
  • migrating cytotrophoblasts: 300 nCPM
  • oocytes: 295 nCPM
  • esophageal basal cells: 151 nCPM
  • late primary spermatocytes: 148 nCPM
  • erythrocyte progenitors: 121 nCPM

Immune cell

  • T-reg: 18 nTPM
  • memory B-cell: 15 nTPM
  • naive B-cell: 11 nTPM
  • memory CD4 T-cell: 8.4 nTPM
  • NK-cell: 8.2 nTPM
  • memory CD8 T-cell: 7.4 nTPM

Brain region

  • pons: 12 nTPM
  • cerebellum: 11 nTPM
  • thalamus: 9.5 nTPM
  • medulla oblongata: 9.3 nTPM
  • cerebral cortex: 8 nTPM
  • midbrain: 7.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCNB1.

Disease | ImmuneIEDB

Conditions an epitope on CCNB1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.16
gnomAD missense Z
0.17
DepMap mean gene effect
-0.79
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNB1 as an antibody target. Whether an autoantibody or antibody against CCNB1 could matter depends on whether native CCNB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCNB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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