Seroatlas · Human Serome Atlas

LAMTOR1

Ragulator complex protein LAMTOR1

Also known as: C11orf59, FLJ20625, LTOR1_HUMAN, p18, p27RF-Rho, Pdro, Ragulator1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6IAA8
Gene
LAMTOR1
Ensembl
ENSG00000149357
Chromosome
11
Canonical length
161 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles,Plasma membrane

OverviewNCBI Gene

Enables GTPase binding activity and protein-membrane adaptor activity. Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of TORC1 signaling; and regulation of cholesterol transport. Located in lysosome. Part of FNIP-folliculin RagC/D GAP. Is active in Ragulator complex and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>Q6IAA8|LAMTOR1
     1  MGCCYSSENE DSDQDREERK LLLDPSSPPT KALNGAEPNY HSLPSARTDE QALLSSILAK
    61  TASNIIDVSA ADSQGMEQHE YMDRARQYST RLAVLSSSLT HWKKLPPLPS LTSQPHQVLA
   121  SEPIPFSDLQ QVSRIAAYAY SALSQIRVDA KEELVVQFGI P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAMTOR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
154 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 154 nTPM
  • kidney: 153 nTPM
  • basal ganglia: 151 nTPM
  • midbrain: 150 nTPM
  • spinal cord: 145 nTPM
  • amygdala: 140 nTPM

Single-cell type

  • platelets: 2,059 nCPM
  • megakaryocytes: 1,199 nCPM
  • hofbauer cells: 630 nCPM
  • esophageal apical cells: 463 nCPM
  • esophageal suprabasal cells: 428 nCPM
  • extravillous trophoblasts: 372 nCPM

Immune cell

  • classical monocyte: 415 nTPM
  • total PBMC: 398 nTPM
  • myeloid DC: 333 nTPM
  • eosinophil: 275 nTPM
  • neutrophil: 231 nTPM
  • intermediate monocyte: 229 nTPM

Brain region

  • midbrain: 130 nTPM
  • medulla oblongata: 129 nTPM
  • thalamus: 128 nTPM
  • basal ganglia: 127 nTPM
  • spinal cord: 125 nTPM
  • pons: 124 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.72
gnomAD missense Z
1.27
DepMap mean gene effect
-0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • LAMTOR1/MEH1
  • Late endosomal/lysosomal adaptor and MAPK and MTOR activator

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LAMTOR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAMTOR1 as an antibody target. Whether an autoantibody or antibody against LAMTOR1 could matter depends on whether native LAMTOR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAMTOR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LAMTOR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LAMTOR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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