Seroatlas · Human Serome Atlas

CDK1

Cyclin-dependent kinase 1

Also known as: CDC2, CDC28A, CDK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P06493
Gene
CDK1
Ensembl
ENSG00000170312
Chromosome
10
Canonical length
297 aa
Protein class
Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Cytosol,Acrosome,Perinuclear theca,Connecting piece,Flagellar centriole

OverviewNCBI Gene

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>P06493|CDK1
     1  MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH
    61  PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKSYLY QILQGIVFCH
   121  SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR
   181  YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT
   241  FPKWKPGSLA SHVKNLDENG LDLLSKMLIY DPAKRISGKM ALNHPYFNDL DNQIKKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 69 nTPM
  • bone marrow: 50 nTPM
  • tonsil: 45 nTPM
  • lymph node: 38 nTPM
  • testis: 24 nTPM
  • rectum: 20 nTPM

Single-cell type

  • late primary spermatocytes: 190 nCPM
  • extravillous trophoblasts: 161 nCPM
  • monocyte progenitors: 159 nCPM
  • gastric progenitor cells: 145 nCPM
  • migrating cytotrophoblasts: 143 nCPM
  • oocytes: 138 nCPM

Immune cell

  • T-reg: 3.4 nTPM
  • NK-cell: 3.3 nTPM
  • memory CD8 T-cell: 1.3 nTPM
  • plasmacytoid DC: 0.9 nTPM
  • total PBMC: 0.9 nTPM
  • memory CD4 T-cell: 0.7 nTPM

Brain region

  • thalamus: 1.5 nTPM
  • pons: 1.1 nTPM
  • medulla oblongata: 1 nTPM
  • white matter: 0.6 nTPM
  • basal ganglia: 0.5 nTPM
  • cerebral cortex: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
0.99
gnomAD missense Z
2.97
DepMap mean gene effect
-2.37
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK1 as an antibody target. Whether an autoantibody or antibody against CDK1 could matter depends on whether native CDK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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