Seroatlas · Human Serome Atlas

LYN

Tyrosine-protein kinase Lyn

Also known as: JTK8, LYN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07948
Gene
LYN
Ensembl
ENSG00000254087
Chromosome
8
Canonical length
512 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>P07948|LYN
     1  MGCIKSKGKD SLSDDGVDLK TQPVRNTERT IYVRDPTSNK QQRPVPESQL LPGQRFQTKD
    61  PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLLTKKE GFIPSNYVAK
   121  LNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DFDPVHGDVI
   181  KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW
   241  EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD
   301  KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER
   361  KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF
   421  TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVENCPD ELYDIMKMCW
   481  KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
80 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 80 nTPM
  • appendix: 75 nTPM
  • bone marrow: 70 nTPM
  • tonsil: 50 nTPM
  • lymph node: 46 nTPM
  • duodenum: 34 nTPM

Single-cell type

  • neutrophils: 6,579 nCPM
  • monocytes: 1,351 nCPM
  • neutrophil progenitors: 1,203 nCPM
  • b-cells: 1,017 nCPM
  • kupffer cells: 651 nCPM
  • pdcs: 628 nCPM

Immune cell

  • neutrophil: 65 nTPM
  • non-classical monocyte: 49 nTPM
  • intermediate monocyte: 28 nTPM
  • eosinophil: 23 nTPM
  • plasmacytoid DC: 16 nTPM
  • naive B-cell: 16 nTPM

Brain region

  • white matter: 22 nTPM
  • medulla oblongata: 19 nTPM
  • thalamus: 19 nTPM
  • cerebral cortex: 18 nTPM
  • choroid plexus: 15 nTPM
  • pons: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LYN.

Disease | AllUniProt

Conditions LYN is implicated in, by any mechanism.

  • Autoinflammatory disease, systemic, with vasculitis (SAIDV) MIM:620376

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 317 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Autoinflammatory disease, systemic, with vasculitis
  • LYN kinase associated vasculopathy and liver fibrosis syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
3.34
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LYN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYN as an antibody target. Whether an autoantibody or antibody against LYN could matter depends on whether native LYN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYN is annotated at the cell surface, where native LYN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LYN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LYN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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