Seroatlas · Human Serome Atlas

CCNE2

G1/S-specific cyclin-E2

Also known as: CCNE2_HUMAN, CYCE2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O96020
Gene: CCNE2
Ensembl: ENSG00000175305
Chromosome: 8
Canonical length: 404 aa
Protein class: Cancer-related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>O96020|CCNE2
     1  MSRRSSRLQA KQQPQPSQTE SPQEAQIIQA KKRKTTQDVK KRREEVTKKH QYEIRNCWPP
    61  VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS PLPDLSWGCS KEVWLNMLKK
   121  ESRYVHDKHF EVLHSDLEPQ MRSILLDWLL EVCEVYTLHR ETFYLAQDFF DRFMLTQKDI
   181  NKNMLQLIGI TSLFIASKLE EIYAPKLQEF AYVTDGACSE EDILRMELII LKALKWELCP
   241  VTIISWLNLF LQVDALKDAP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILTAAA
   301  LCHFTSIEVV KKASGLEWDS ISECVDWMVP FVNVVKSTSP VKLKTFKKIP MEDRHNIQTH
   361  TNYLAMLEEV NYINTFRKGG QLSPVCNGGI MTPPKSTEKP PGKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 35 nTPM
spinal cord: 17 nTPM
thymus: 14 nTPM
testis: 14 nTPM
lymph node: 10 nTPM
tonsil: 9 nTPM

Single-cell type

early primary spermatocytes: 90 nCPM
erythrocyte progenitors: 45 nCPM
monocyte progenitors: 44 nCPM
late primary spermatocytes: 43 nCPM
megakaryocyte progenitors: 40 nCPM
neutrophil progenitors: 39 nCPM

Immune cell

T-reg: 5.2 nTPM
NK-cell: 1.5 nTPM
memory CD8 T-cell: 1.3 nTPM
memory CD4 T-cell: 1.1 nTPM
naive B-cell: 1.1 nTPM
gdT-cell: 0.8 nTPM

Brain region

white matter: 32 nTPM
medulla oblongata: 26 nTPM
cerebellum: 23 nTPM
basal ganglia: 21 nTPM
midbrain: 21 nTPM
thalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.87
gnomAD missense Z: 1.5
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNE2 as an antibody target. Whether an autoantibody or antibody against CCNE2 could matter depends on whether native CCNE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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