Seroatlas · Human Serome Atlas

CCNA2

Cyclin-A2

Also known as: CCN1, CCNA, CCNA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P20248
Gene
CCNA2
Ensembl
ENSG00000145386
Chromosome
4
Canonical length
432 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>P20248|CCNA2
     1  MLGNSAPGPA TREAGSALLA LQQTALQEDQ ENINPEKAAP VQQPRTRAAL AVLKSGNPRG
    61  LAQQQRPKTR RVAPLKDLPV NDEHVTVPPW KANSKQPAFT IHVDEAEKEA QKKPAESQKI
   121  EREDALAFNS AISLPGPRKP LVPLDYPMDG SFESPHTMDM SIILEDEKPV SVNEVPDYHE
   181  DIHTYLREME VKCKPKVGYM KKQPDITNSM RAILVDWLVE VGEEYKLQNE TLHLAVNYID
   241  RFLSSMSVLR GKLQLVGTAA MLLASKFEEI YPPEVAEFVY ITDDTYTKKQ VLRMEHLVLK
   301  VLTFDLAAPT VNQFLTQYFL HQQPANCKVE SLAMFLGELS LIDADPYLKY LPSVIAGAAF
   361  HLALYTVTGQ SWPESLIRKT GYTLESLKPC LMDLHQTYLK APQHAQQSIR EKYKNSKYHG
   421  VSLLNPPETL NL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 44 nTPM
  • bone marrow: 36 nTPM
  • retina: 29 nTPM
  • lymph node: 23 nTPM
  • tonsil: 23 nTPM
  • esophagus: 11 nTPM

Single-cell type

  • monocyte progenitors: 144 nCPM
  • erythrocyte progenitors: 123 nCPM
  • extravillous trophoblasts: 97 nCPM
  • migrating cytotrophoblasts: 92 nCPM
  • megakaryocyte progenitors: 65 nCPM
  • enteric transient amplifying cells: 60 nCPM

Immune cell

  • T-reg: 3.2 nTPM
  • memory CD4 T-cell: 0.9 nTPM
  • total PBMC: 0.9 nTPM
  • NK-cell: 0.8 nTPM
  • memory CD8 T-cell: 0.6 nTPM
  • myeloid DC: 0.4 nTPM

Brain region

  • cerebellum: 4.7 nTPM
  • white matter: 4.6 nTPM
  • medulla oblongata: 3.6 nTPM
  • midbrain: 3.4 nTPM
  • cerebral cortex: 3.3 nTPM
  • thalamus: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.13
gnomAD pLI
1
gnomAD missense Z
2.22
DepMap mean gene effect
-1.31
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNA2 as an antibody target. Whether an autoantibody or antibody against CCNA2 could matter depends on whether native CCNA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCNA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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