CDK2
Cyclin-dependent kinase 2
Also known as: CDK2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P24941
- Gene
- CDK2
- Ensembl
- ENSG00000123374
- Chromosome
- 12
- Canonical length
- 298 aa
- Protein class
- Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Centrosome
OverviewNCBI Gene
This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Canonical amino-acid sequenceUniProt
298 residues, UniProt reviewed canonical sequence.
>P24941|CDK2
1 MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH
61 PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS
121 HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY
181 STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF
241 PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CDK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.26
- Highest tissue expression
- 44 nTPM
Expression across tissuesHPA
Tissue
- placenta: 44 nTPM
- thymus: 35 nTPM
- bone marrow: 34 nTPM
- tonsil: 23 nTPM
- lung: 22 nTPM
- skin: 22 nTPM
Single-cell type
- syncytiotrophoblasts: 245 nCPM
- migrating cytotrophoblasts: 145 nCPM
- melanocytes: 142 nCPM
- cytotrophoblasts: 120 nCPM
- extravillous trophoblasts: 99 nCPM
- erythrocyte progenitors: 36 nCPM
Immune cell
- plasmacytoid DC: 7.9 nTPM
- memory B-cell: 6.5 nTPM
- T-reg: 5.4 nTPM
- gdT-cell: 4.7 nTPM
- MAIT T-cell: 4.6 nTPM
- naive B-cell: 3.7 nTPM
Brain region
- choroid plexus: 8.2 nTPM
- medulla oblongata: 4.9 nTPM
- spinal cord: 4 nTPM
- thalamus: 3.9 nTPM
- pons: 3.8 nTPM
- midbrain: 3.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.49
- gnomAD pLI
- 0.61
- gnomAD missense Z
- 2.49
- DepMap mean gene effect
- -0.68
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell division
- cellular response to nitric oxide
- cellular senescence
- centriole replication
- centrosome duplication
- chromatin remodeling
- DNA repair
- DNA replication
- DNA-templated transcription
- G1/S transition of mitotic cell cycle
- G2/M transition of mitotic cell cycle
- meiotic cell cycle
- mitotic G1 DNA damage checkpoint signaling
- negative regulation of protein localization to chromatin
- negative regulation of transcription by RNA polymerase II
- peptidyl-serine phosphorylation
- positive regulation of cell population proliferation
- positive regulation of DNA replication
- positive regulation of DNA-templated DNA replication initiation
- positive regulation of DNA-templated transcription
- positive regulation of heterochromatin formation
- post-translational protein modification
- potassium ion transport
- protein phosphorylation
- Ras protein signal transduction
- regulation of anaphase-promoting complex-dependent catabolic process
- regulation of G2/M transition of mitotic cell cycle
- regulation of gene expression
- regulation of heterochromatin organization
- regulation of mitotic cell cycle
- signal transduction
- telomere maintenance in response to DNA damage
Molecular functions
- ATP binding
- cyclin binding
- cyclin-dependent protein kinase activity
- cyclin-dependent protein serine/threonine kinase activity
- magnesium ion binding
- protein domain specific binding
- protein serine kinase activity
- protein serine/threonine kinase activity
Cellular components
- Cajal body
- centrosome
- chromosome, telomeric region
- condensed chromosome
- cyclin A1-CDK2 complex
- cyclin A2-CDK2 complex
- cyclin E1-CDK2 complex
- cyclin E2-CDK2 complex
- cyclin-dependent protein kinase holoenzyme complex
- cytoplasm
- cytosol
- endosome
- male germ cell nucleus
- nuclear envelope
- nucleoplasm
- nucleus
- transcription regulator complex
- X chromosome
- Y chromosome
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CDK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CDK2 as an antibody target. Whether an autoantibody or antibody against CDK2 could matter depends on whether native CDK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CDK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CDK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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