Seroatlas · Human Serome Atlas

CCNA1

Cyclin-A1

Also known as: CCNA1_HUMAN, CT146

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78396
Gene: CCNA1
Ensembl: ENSG00000133101
Chromosome: 13
Canonical length: 465 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>P78396|CCNA1
     1  METGFPAIMY PGSFIGGWGE EYLSWEGPGL PDFVFQQQPV ESEAMHCSNP KSGVVLATVA
    61  RGPDACQILT RAPLGQDPPQ RTVLGLLTAN GQYRRTCGQG ITRIRCYSGS ENAFPPAGKK
   121  ALPDCGVQEP PKQGFDIYMD ELEQGDRDSC SVREGMAFED VYEVDTGTLK SDLHFLLDFN
   181  TVSPMLVDSS LLSQSEDISS LGTDVINVTE YAEEIYQYLR EAEIRHRPKA HYMKKQPDIT
   241  EGMRTILVDW LVEVGEEYKL RAETLYLAVN FLDRFLSCMS VLRGKLQLVG TAAMLLASKY
   301  EEIYPPEVDE FVYITDDTYT KRQLLKMEHL LLKVLAFDLT VPTTNQFLLQ YLRRQGVCVR
   361  TENLAKYVAE LSLLEADPFL KYLPSLIAAA AFCLANYTVN KHFWPETLAA FTGYSLSEIV
   421  PCLSELHKAY LDIPHRPQQA IREKYKASKY LCVSLMEPPA VLLLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

testis: 76 nTPM
parathyroid gland: 21 nTPM
fallopian tube: 17 nTPM
basal ganglia: 12 nTPM
hypothalamus: 9.3 nTPM
choroid plexus: 8 nTPM

Single-cell type

late primary spermatocytes: 555 nCPM
early spermatids: 121 nCPM
late spermatids: 113 nCPM
fallopian tube ciliated cells: 101 nCPM
endometrial ciliated cells: 97 nCPM
fallopian secretory cells: 51 nCPM

Immune cell

basophil: 50 nTPM
eosinophil: 0.4 nTPM
naive B-cell: 0.1 nTPM
T-reg: 0.1 nTPM
total PBMC: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

pons: 20 nTPM
hypothalamus: 13 nTPM
cerebral cortex: 10 nTPM
basal ganglia: 10 nTPM
midbrain: 9.7 nTPM
medulla oblongata: 9.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCNA1.

Disease | ImmuneIEDB

Conditions an epitope on CCNA1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 1.25
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cyclin-dependent protein serine/threonine kinase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNA1 as an antibody target. Whether an autoantibody or antibody against CCNA1 could matter depends on whether native CCNA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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