Seroatlas · Human Serome Atlas

CCNE1

G1/S-specific cyclin-E1

Also known as: CCNE, CCNE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P24864
Gene
CCNE1
Ensembl
ENSG00000105173
Chromosome
19
Canonical length
410 aa
Protein class
Cancer-related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>P24864|CCNE1
     1  MPRERRERDA KERDTMKEDG GAEFSARSRK RKANVTVFLQ DPDEEMAKID RTARDQCGSQ
    61  PWDNNAVCAD PCSLIPTPDK EDDDRVYPNS TCKPRIIAPS RGSPLPVLSW ANREEVWKIM
   121  LNKEKTYLRD QHFLEQHPLL QPKMRAILLD WLMEVCEVYK LHRETFYLAQ DFFDRYMATQ
   181  ENVVKTLLQL IGISSLFIAA KLEEIYPPKL HQFAYVTDGA CSGDEILTME LMIMKALKWR
   241  LSPLTIVSWL NVYMQVAYLN DLHEVLLPQY PQQIFIQIAE LLDLCVLDVD CLEFPYGILA
   301  ASALYHFSSS ELMQKVSGYQ WCDIENCVKW MVPFAMVIRE TGSSKLKHFR GVADEDAHNI
   361  QTHRDSLDLL DKARAKKAML SEQNRASPLP SGLLTPPQSG KKQSSGPEMA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 34 nTPM
  • placenta: 29 nTPM
  • testis: 12 nTPM
  • tonsil: 7.3 nTPM
  • lymph node: 5.7 nTPM
  • adrenal gland: 5.4 nTPM

Single-cell type

  • extravillous trophoblasts: 2,490 nCPM
  • migrating cytotrophoblasts: 401 nCPM
  • cytotrophoblasts: 139 nCPM
  • erythrocyte progenitors: 90 nCPM
  • syncytiotrophoblasts: 54 nCPM
  • late primary spermatocytes: 36 nCPM

Immune cell

  • memory B-cell: 0.6 nTPM
  • intermediate monocyte: 0.5 nTPM
  • non-classical monocyte: 0.5 nTPM
  • myeloid DC: 0.4 nTPM
  • neutrophil: 0.4 nTPM
  • MAIT T-cell: 0.3 nTPM

Brain region

  • cerebellum: 5 nTPM
  • cerebral cortex: 5 nTPM
  • hypothalamus: 4.6 nTPM
  • thalamus: 4.5 nTPM
  • white matter: 4 nTPM
  • basal ganglia: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
1.53
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNE1 as an antibody target. Whether an autoantibody or antibody against CCNE1 could matter depends on whether native CCNE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCNE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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