Seroatlas · Human Serome Atlas

CKS1B

Cyclin-dependent kinases regulatory subunit 1

Also known as: CKS1, CKS1_HUMAN, ckshs1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61024
Gene: CKS1B
Ensembl: ENSG00000173207
Chromosome: 1
Canonical length: 79 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Mitochondria,Cytosol
Quaternary structure: Homohexamer

OverviewNCBI Gene

CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>P61024|CKS1B
     1  MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ SQGWVHYMIH
    61  EPEPHILLFR RPLPKKPKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CKS1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 111 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 111 nTPM
thymus: 83 nTPM
tonsil: 69 nTPM
liver: 68 nTPM
lymph node: 67 nTPM
breast: 63 nTPM

Single-cell type

extravillous trophoblasts: 526 nCPM
gastric progenitor cells: 435 nCPM
oocytes: 332 nCPM
migrating cytotrophoblasts: 266 nCPM
enteric transient amplifying cells: 170 nCPM
cytotrophoblasts: 147 nCPM

Immune cell

non-classical monocyte: 106 nTPM
plasmacytoid DC: 93 nTPM
intermediate monocyte: 82 nTPM
memory B-cell: 75 nTPM
naive B-cell: 71 nTPM
naive CD4 T-cell: 34 nTPM

Brain region

white matter: 17 nTPM
medulla oblongata: 15 nTPM
spinal cord: 14 nTPM
pons: 13 nTPM
cerebellum: 12 nTPM
hypothalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0.43
gnomAD missense Z: 1.31
DepMap mean gene effect: -0.72
DepMap dependency class: common

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CKS1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CKS1B as an antibody target. Whether an autoantibody or antibody against CKS1B could matter depends on whether native CKS1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CKS1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CKS1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...