Seroatlas · Human Serome Atlas

YWHAH

14-3-3 protein eta

Also known as: 1433F_HUMAN, YWHA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q04917
Gene: YWHAH
Ensembl: ENSG00000128245
Chromosome: 22
Canonical length: 246 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>Q04917|YWHAH
     1  MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK NVVGARRSSW
    61  RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV LSLLDKFLIK NCNDFQYESK
   121  VFYLKMKGDY YRYLAEVASG EKKNSVVEAS EAAYKEAFEI SKEQMQPTHP IRLGLALNFS
   181  VFYYEIQNAP EQACLLAKQA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE
   241  EAGEGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YWHAH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 728 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 728 nTPM
amygdala: 504 nTPM
hippocampal formation: 396 nTPM
hypothalamus: 332 nTPM
blood vessel: 288 nTPM
basal ganglia: 254 nTPM

Single-cell type

platelets: 2,831 nCPM
megakaryocytes: 1,014 nCPM
foveolar cells: 338 nCPM
neutrophil progenitors: 324 nCPM
smooth muscle cells: 314 nCPM
respiratory deuterosomal cells: 238 nCPM

Immune cell

NK-cell: 26 nTPM
myeloid DC: 23 nTPM
eosinophil: 22 nTPM
classical monocyte: 20 nTPM
T-reg: 20 nTPM
non-classical monocyte: 19 nTPM

Brain region

cerebral cortex: 943 nTPM
basal ganglia: 699 nTPM
hippocampal formation: 645 nTPM
hypothalamus: 577 nTPM
white matter: 576 nTPM
amygdala: 526 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.78
gnomAD missense Z: 2.56
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YWHAH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YWHAH as an antibody target. Whether an autoantibody or antibody against YWHAH could matter depends on whether native YWHAH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YWHAH is annotated at the cell surface, where native YWHAH is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label YWHAH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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