Seroatlas · Human Serome Atlas

CDK4

Cyclin-dependent kinase 4

Also known as: CDK4_HUMAN, PSK-J3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P11802
Gene
CDK4
Ensembl
ENSG00000135446
Chromosome
12
Canonical length
303 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Nucleoli,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>P11802|CDK4
     1  MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGGGGGLP ISTVREVALL
    61  RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHVDQDL RTYLDKAPPP GLPAETIKDL
   121  MRQFLRGLDF LHANCIVHRD LKPENILVTS GGTVKLADFG LARIYSYQMA LTPVVVTLWY
   181  RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR
   241  DVSLPRGAFP PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKDEG
   301  NPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
115 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 115 nTPM
  • endometrium: 92 nTPM
  • adrenal gland: 88 nTPM
  • cervix: 83 nTPM
  • smooth muscle: 75 nTPM
  • pancreas: 73 nTPM

Single-cell type

  • hofbauer cells: 197 nCPM
  • decidual stromal cells: 195 nCPM
  • esophageal basal cells: 181 nCPM
  • migrating cytotrophoblasts: 147 nCPM
  • erythrocyte progenitors: 145 nCPM
  • extravillous trophoblasts: 144 nCPM

Immune cell

  • memory B-cell: 94 nTPM
  • naive CD4 T-cell: 93 nTPM
  • naive B-cell: 90 nTPM
  • plasmacytoid DC: 85 nTPM
  • naive CD8 T-cell: 85 nTPM
  • MAIT T-cell: 82 nTPM

Brain region

  • basal ganglia: 29 nTPM
  • cerebellum: 29 nTPM
  • spinal cord: 29 nTPM
  • thalamus: 29 nTPM
  • hypothalamus: 28 nTPM
  • medulla oblongata: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDK4.

Disease | AllUniProt

Conditions CDK4 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 1,313 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on CDK4 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.06
gnomAD missense Z
1.49
DepMap mean gene effect
-0.76
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK4 as an antibody target. Whether an autoantibody or antibody against CDK4 could matter depends on whether native CDK4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDK4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDK4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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