Seroatlas · Human Serome Atlas

SPDYA

Speedy protein A

Also known as: Ringo3, SPDY1, SPDYA_HUMAN, SPY1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5MJ70
Gene: SPDYA
Ensembl: ENSG00000163806
Chromosome: 2
Canonical length: 313 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables protein kinase activator activity and protein kinase binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of cell population proliferation; and positive regulation of protein kinase activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q5MJ70|SPDYA
     1  MRHNQMCCET PPTVTVYVKS GSNRSHQPKK PITLKRPICK DNWQAFEKNT HNNNKSKRPK
    61  GPCLVIQRQD MTAFFKLFDD DLIQDFLWMD CCCKIADKYL LAMTFVYFKR AKFTISEHTR
   121  INFFIALYLA NTVEEDEEET KYEIFPWALG KNWRKLFPNF LKLRDQLWDR IDYRAIVSRR
   181  CCEEVMAIAP THYIWQRERS VHHSGAVRNY NRDEVQLPRG PSATPVDCSL CGKKRRYVRL
   241  GLSSSSSLSS HTAGVTEKHS QDSYNSLSMD IIGDPSQAYT GSEVVNDHQS NKGKKTNFLK
   301  KDKSMEWFTG SEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

testis: 31 nTPM
cerebellum: 2.3 nTPM
spleen: 1.7 nTPM
prostate: 1.6 nTPM
skin: 1.5 nTPM
liver: 1.4 nTPM

Single-cell type

early primary spermatocytes: 497 nCPM
neutrophils: 357 nCPM
late primary spermatocytes: 337 nCPM
endometrial luminal cells: 210 nCPM
endometrial ciliated cells: 134 nCPM
endometrial glandular cells: 128 nCPM

Immune cell

gdT-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 2.7 nTPM
hippocampal formation: 2.7 nTPM
cerebellum: 2.6 nTPM
amygdala: 2.5 nTPM
basal ganglia: 2.3 nTPM
hypothalamus: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.55
gnomAD missense Z: 1.56
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPDYA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYA as an antibody target. Whether an autoantibody or antibody against SPDYA could matter depends on whether native SPDYA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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