Seroatlas · Human Serome Atlas

CDK6

Cyclin-dependent kinase 6

Also known as: CDK6_HUMAN, PLSTIRE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q00534
Gene
CDK6
Ensembl
ENSG00000105810
Chromosome
7
Canonical length
326 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>Q00534|CDK6
     1  MEKDGLCRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTG EEGMPLSTIR
    61  EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE
   121  TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV
   181  VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDVIGLPGE
   241  EDWPRDVALP RQAFHSKSAQ PIEKFVTDID ELGKDLLLKC LTFNPAKRIS AYSALSHPYF
   301  QDLERCKENL DSHLPPSQNT SELNTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 38 nTPM
  • bone marrow: 17 nTPM
  • placenta: 16 nTPM
  • parathyroid gland: 9.3 nTPM
  • stomach: 8.5 nTPM
  • rectum: 7 nTPM

Single-cell type

  • megakaryocyte-erythroid progenitors: 1,460 nCPM
  • thymocytes: 1,314 nCPM
  • megakaryocyte progenitors: 1,154 nCPM
  • hematopoietic stem cells: 1,044 nCPM
  • adrenal cortex cells: 660 nCPM
  • paneth cells: 514 nCPM

Immune cell

  • basophil: 1 nTPM
  • MAIT T-cell: 0.9 nTPM
  • plasmacytoid DC: 0.9 nTPM
  • memory CD8 T-cell: 0.8 nTPM
  • naive CD4 T-cell: 0.7 nTPM
  • naive CD8 T-cell: 0.7 nTPM

Brain region

  • thalamus: 22 nTPM
  • white matter: 20 nTPM
  • basal ganglia: 17 nTPM
  • amygdala: 16 nTPM
  • midbrain: 16 nTPM
  • medulla oblongata: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDK6.

Disease | AllUniProt

Conditions CDK6 is implicated in, by any mechanism.

  • Microcephaly 12, primary, autosomal recessive (MCPH12) MIM:616080

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 53 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Microcephaly 12, primary, autosomal recessive

Disease | ImmuneIEDB

Conditions an epitope on CDK6 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.98
gnomAD missense Z
3.06
DepMap mean gene effect
-0.59
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK6 as an antibody target. Whether an autoantibody or antibody against CDK6 could matter depends on whether native CDK6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDK6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDK6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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