Seroatlas · Human Serome Atlas

CNOT6L

CCR4-NOT transcription complex subunit 6-like

Also known as: Ccr4b, CNO6L_HUMAN, DKFZp434K098

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96LI5
Gene
CNOT6L
Ensembl
ENSG00000138767
Chromosome
4
Canonical length
555 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable 3'-5'-RNA exonuclease activity. Involved in positive regulation of cell population proliferation and positive regulation of cytoplasmic mRNA processing body assembly. Located in cytosol and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

555 residues, UniProt reviewed canonical sequence.

>Q96LI5|CNOT6L
     1  MRLIGMPKEK YDPPDPRRIY TIMSAEEVAN GKKSHWAELE ISGRVRSLST SLWSLTHLTA
    61  LHLNDNYLSR IPPDIAKLHN LVYLDLSSNK LRSLPAELGN MVSLRELLLN NNLLRVLPYE
   121  LGRLFQLQTL GLKGNPLSQD ILNLYQDPDG TRKLLNFMLD NLAVHPEQLP PRPWITLKER
   181  DQILPSASFT VMCYNVLCDK YATRQLYGYC PSWALNWEYR KKGIMEEIVN CDADIISLQE
   241  VETEQYFTLF LPALKERGYD GFFSPKSRAK IMSEQERKHV DGCAIFFKTE KFTLVQKHTV
   301  EFNQVAMANS DGSEAMLNRV MTKDNIGVAV VLEVHKELFG AGMKPIHAAD KQLLIVANAH
   361  MHWDPEYSDV KLIQTMMFVS EVKNILEKAS SRPGSPTADP NSIPLVLCAD LNSLPDSGVV
   421  EYLSNGGVAD NHKDFKELRY NECLMNFSCN GKNGSSEGRI THGFQLKSAY ENNLMPYTNY
   481  TFDFKGVIDY IFYSKTHMNV LGVLGPLDPQ WLVENNITGC PHPHIPSDHF SLLTQLELHP
   541  PLLPLVNGVH LPNRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNOT6L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 42 nTPM
  • tonsil: 33 nTPM
  • lymph node: 32 nTPM
  • bone marrow: 24 nTPM
  • spleen: 21 nTPM
  • appendix: 20 nTPM

Single-cell type

  • t-cells: 1,250 nCPM
  • nk-cells: 1,164 nCPM
  • innate lymphoid cells: 661 nCPM
  • distal convoluted tubule cells: 381 nCPM
  • thymocytes: 376 nCPM
  • b-cells: 308 nCPM

Immune cell

  • eosinophil: 6.3 nTPM
  • basophil: 6.1 nTPM
  • non-classical monocyte: 5.9 nTPM
  • naive CD8 T-cell: 5.3 nTPM
  • gdT-cell: 5.1 nTPM
  • MAIT T-cell: 4.9 nTPM

Brain region

  • cerebellum: 35 nTPM
  • hypothalamus: 29 nTPM
  • thalamus: 26 nTPM
  • spinal cord: 25 nTPM
  • white matter: 25 nTPM
  • midbrain: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
3.61
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNOT6L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNOT6L as an antibody target. Whether an autoantibody or antibody against CNOT6L could matter depends on whether native CNOT6L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNOT6L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNOT6L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CNOT6L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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