Seroatlas · Human Serome Atlas

CNOT2

CCR4-NOT transcription complex subunit 2

Also known as: CDC36, CNOT2_HUMAN, NOT2, NOT2H

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZN8
Gene
CNOT2
Ensembl
ENSG00000111596
Chromosome
12
Canonical length
540 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>Q9NZN8|CNOT2
     1  MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF PHRSEKDMLA
    61  SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL SQGTQLPSHV TPTTGVPTMS
   121  LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ
   181  PSRQPFTVNS MSGFGMNRNQ AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE
   241  GSGNPTPLIN PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS
   301  NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM VTDQFGMIGL
   361  LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA SPWASSPCRP QDIDFHVPSE
   421  YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM NGGDVLQLLA AVELFNRDWR YHKEERVWIT
   481  RAPGMEPTMK TNTYERGTYY FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNOT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 74 nTPM
  • cerebellum: 59 nTPM
  • skin: 48 nTPM
  • thymus: 47 nTPM
  • retina: 43 nTPM
  • tonsil: 40 nTPM

Single-cell type

  • nk-cells: 404 nCPM
  • innate lymphoid cells: 374 nCPM
  • pdcs: 341 nCPM
  • somatotrophs: 298 nCPM
  • neutrophils: 279 nCPM
  • microglia: 267 nCPM

Immune cell

  • basophil: 92 nTPM
  • intermediate monocyte: 70 nTPM
  • naive CD8 T-cell: 68 nTPM
  • naive CD4 T-cell: 63 nTPM
  • NK-cell: 62 nTPM
  • myeloid DC: 60 nTPM

Brain region

  • cerebellum: 151 nTPM
  • white matter: 100 nTPM
  • medulla oblongata: 81 nTPM
  • thalamus: 81 nTPM
  • basal ganglia: 78 nTPM
  • pons: 78 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CNOT2.

Disease | AllUniProt

Conditions CNOT2 is implicated in, by any mechanism.

  • Intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies (IDNADFS) MIM:618608

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 90 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies
  • Neurodevelopmental disorder
  • Inborn genetic diseases
  • ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
3.65
DepMap mean gene effect
-0.49
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNOT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNOT2 as an antibody target. Whether an autoantibody or antibody against CNOT2 could matter depends on whether native CNOT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNOT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNOT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CNOT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...