Seroatlas · Human Serome Atlas

ARPC3

Actin-related protein 2/3 complex subunit 3

Also known as: ARC21, ARPC3_HUMAN, p21-Arc

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15145
Gene: ARPC3
Ensembl: ENSG00000111229
Chromosome: 12
Canonical length: 178 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>O15145|ARPC3
     1  MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK ANVFFKNYEI
    61  KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI TNFPIPGEPG FPLNAIYAKP
   121  ANKQEDEVMR AYLQQLRQET GLRLCEKVFD PQNDKPSKWW TCFVKRQFMN KSLSGPGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARPC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 731 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 731 nTPM
lymph node: 540 nTPM
tonsil: 537 nTPM
esophagus: 381 nTPM
spleen: 377 nTPM
appendix: 345 nTPM

Single-cell type

esophageal apical cells: 693 nCPM
megakaryocytes: 575 nCPM
hofbauer cells: 572 nCPM
neutrophils: 514 nCPM
kupffer cells: 428 nCPM
cdc: 406 nCPM

Immune cell

eosinophil: 1,665 nTPM
neutrophil: 1,616 nTPM
total PBMC: 1,548 nTPM
non-classical monocyte: 1,425 nTPM
basophil: 1,318 nTPM
intermediate monocyte: 1,184 nTPM

Brain region

white matter: 115 nTPM
medulla oblongata: 101 nTPM
hypothalamus: 96 nTPM
spinal cord: 91 nTPM
basal ganglia: 87 nTPM
pons: 87 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.22
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.87
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Actin-related protein 2/3 complex subunit 3
Actin-related protein 2/3 complex subunit 3 superfamily
ARP2/3 complex ARPC3 (21 kDa) subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARPC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARPC3 as an antibody target. Whether an autoantibody or antibody against ARPC3 could matter depends on whether native ARPC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARPC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARPC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...