Seroatlas · Human Serome Atlas

CNOT6

CCR4-NOT transcription complex subunit 6

Also known as: CCR4, Ccr4a, CNOT6_HUMAN, KIAA1194

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULM6
Gene
CNOT6
Ensembl
ENSG00000113300
Chromosome
5
Canonical length
557 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

557 residues, UniProt reviewed canonical sequence.

>Q9ULM6|CNOT6
     1  MPKEKYEPPD PRRMYTIMSS EEAANGKKSH WAELEISGKV RSLSASLWSL THLTALHLSD
    61  NSLSRIPSDI AKLHNLVYLD LSSNKIRSLP AELGNMVSLR ELHLNNNLLR VLPFELGKLF
   121  QLQTLGLKGN PLTQDILNLY QEPDGTRRLL NYLLDNLSGT AKRITTEQPP PRSWIMLQEP
   181  DRTRPTALFS VMCYNVLCDK YATRQLYGYC PSWALNWDYR KKAIIQEILS CNADIVSLQE
   241  VETEQYYSFF LVELKERGYN GFFSPKSRAR TMSEQERKHV DGCAIFFKTE KFTLVQKHTV
   301  EFNQLAMANS EGSEAMLNRV MTKDNIGVAV LLELRKESIE MPSGKPHLGT EKQLILVANA
   361  HMHWDPEYSD VKLVQTMMFL SEVKNIIDKA SRNLKSSVLG EFGTIPLVLC ADLNSLPDSG
   421  VVEYLSTGGV ETNHKDFKEL RYNESLTNFS CHGKNGTTNG RITHGFKLQS AYESGLMPYT
   481  NYTFDFKGII DYIFYSKPQL NTLGILGPLD HHWLVENNIS GCPHPLIPSD HFSLFAQLEL
   541  LLPFLPQVNG IHLPGRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNOT6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 18 nTPM
  • retina: 16 nTPM
  • cerebellum: 14 nTPM
  • tonsil: 13 nTPM
  • testis: 13 nTPM
  • duodenum: 11 nTPM

Single-cell type

  • neutrophil progenitors: 139 nCPM
  • erythrocyte progenitors: 97 nCPM
  • endometrial ciliated cells: 97 nCPM
  • early primary spermatocytes: 85 nCPM
  • differentiating spermatogonia: 83 nCPM
  • gonadotrophs: 82 nCPM

Immune cell

  • non-classical monocyte: 2.3 nTPM
  • intermediate monocyte: 1.4 nTPM
  • naive CD4 T-cell: 1.4 nTPM
  • naive CD8 T-cell: 1.4 nTPM
  • MAIT T-cell: 1.3 nTPM
  • eosinophil: 1.2 nTPM

Brain region

  • cerebellum: 33 nTPM
  • choroid plexus: 21 nTPM
  • hypothalamus: 20 nTPM
  • thalamus: 19 nTPM
  • white matter: 19 nTPM
  • medulla oblongata: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.02
gnomAD missense Z
2.38
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNOT6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNOT6 as an antibody target. Whether an autoantibody or antibody against CNOT6 could matter depends on whether native CNOT6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNOT6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNOT6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CNOT6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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