Seroatlas · Human Serome Atlas

CSDE1

Cold shock domain-containing protein E1

Also known as: CSDE1_HUMAN, D1S155E, UNR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75534
Gene: CSDE1
Ensembl: ENSG00000009307
Chromosome: 1
Canonical length: 798 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables RISC complex binding activity; RNA stem-loop binding activity; and lncRNA binding activity. Involved in IRES-dependent viral translational initiation; regulation of gene expression; and stress granule assembly. Located in Golgi apparatus; cytosol; and plasma membrane. Part of CRD-mediated mRNA stability complex and mCRD-mediated mRNA stability complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

798 residues, UniProt reviewed canonical sequence.

>O75534|CSDE1
     1  MSFDPNLLHN NGHNGYPNGT SAALRETGVI EKLLTSYGFI QCSERQARLF FHCSQYNGNL
    61  QDLKVGDDVE FEVSSDRRTG KPIAVKLVKI KQEILPEERM NGQVVCAVPH NLESKSPAAP
   121  GQSPTGSVCY ERNGEVFYLT YTPEDVEGNV QLETGDKINF VIDNNKHTGA VSARNIMLLK
   181  KKQARCQGVV CAMKEAFGFI ERGDVVKEIF FHYSEFKGDL ETLQPGDDVE FTIKDRNGKE
   241  VATDVRLLPQ GTVIFEDISI EHFEGTVTKV IPKVPSKNQN DPLPGRIKVD FVIPKELPFG
   301  DKDTKSKVTL LEGDHVRFNI STDRRDKLER ATNIEVLSNT FQFTNEAREM GVIAAMRDGF
   361  GFIKCVDRDV RMFFHFSEIL DGNQLHIADE VEFTVVPDML SAQRNHAIRI KKLPKGTVSF
   421  HSHSDHRFLG TVEKEATFSN PKTTSPNKGK EKEAEDGIIA YDDCGVKLTI AFQAKDVEGS
   481  TSPQIGDKVE FSISDKQRPG QQVATCVRLL GRNSNSKRLL GYVATLKDNF GFIETANHDK
   541  EIFFHYSEFS GDVDSLELGD MVEYSLSKGK GNKVSAEKVN KTHSVNGITE EADPTIYSGK
   601  VIRPLRSVDP TQTEYQGMIE IVEEGDMKGE VYPFGIVGMA NKGDCLQKGE SVKFQLCVLG
   661  QNAQTMAYNI TPLRRATVEC VKDQFGFINY EVGDSKKLFF HVKEVQDGIE LQAGDEVEFS
   721  VILNQRTGKC SACNVWRVCE GPKAVAAPRP DRLVNRLKNI TLDDASAPRL MVLRQPRGPD
   781  NSMGFGAERK IRQAGVID

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSDE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 1,250 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 1,250 nTPM
tongue: 935 nTPM
adipose tissue: 378 nTPM
heart muscle: 372 nTPM
blood vessel: 253 nTPM
parathyroid gland: 251 nTPM

Single-cell type

late spermatids: 939 nCPM
esophageal apical cells: 613 nCPM
thymic myoid cells: 559 nCPM
late primary spermatocytes: 554 nCPM
smooth muscle cells: 452 nCPM
myonuclei: 377 nCPM

Immune cell

total PBMC: 381 nTPM
non-classical monocyte: 265 nTPM
classical monocyte: 235 nTPM
intermediate monocyte: 227 nTPM
eosinophil: 222 nTPM
myeloid DC: 221 nTPM

Brain region

white matter: 237 nTPM
spinal cord: 237 nTPM
hypothalamus: 230 nTPM
midbrain: 229 nTPM
medulla oblongata: 224 nTPM
thalamus: 222 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CSDE1.

Disease | GeneticClinVar

18 pathogenic / likely-pathogenic of 219 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Inborn genetic diseases
CSDE1-associated disorder
CSDE1-related neurodevelopmental disorder
Autism
Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 3.45
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cold-shock protein Csp, DNA-binding
Cold-shock domain
Nucleic acid-binding, OB-fold
Cold-shock domain, conserved site
SUZ-C domain
'Cold-shock' DNA-binding domain
SUZ-C motif
Cold shock domain-containing protein E1, CSD domain
Cold shock domain-containing protein E1 CSD domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSDE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSDE1 as an antibody target. Whether an autoantibody or antibody against CSDE1 could matter depends on whether native CSDE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSDE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSDE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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