Seroatlas · Human Serome Atlas

CNOT11

CCR4-NOT transcription complex subunit 11

Also known as: C2orf29, C40, CNO11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKZ1
Gene
CNOT11
Ensembl
ENSG00000158435
Chromosome
2
Canonical length
510 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>Q9UKZ1|CNOT11
     1  MPGGGASAAS GRLLTAAEQR GSREAAGSAS RSGFGGSGGG RGGASGPGSG SGGPGGPAGR
    61  MSLTPKELSS LLSIISEEAG GGSTFEGLST AFHHYFSKAD HFRLGSVLVM LLQQPDLLPS
   121  AAQRLTALYL LWEMYRTEPL AANPFAASFA HLLNPAPPAR GGQEPDRPPL SGFLPPITPP
   181  EKFFLSQLML APPRELFKKT PRQIALMDVG NMGQSVDISG LQLALAERQS ELPTQSKASF
   241  PSILSDPDPD SSNSGFDSSV ASQITEALVS GPKPPIESHF RPEFIRPPPP LHICEDELAW
   301  LNPTEPDHAI QWDKSMCVKN STGVEIKRIM AKAFKSPLSS PQQTQLLGEL EKDPKLVYHI
   361  GLTPAKLPDL VENNPLVAIE MLLKLMQSSQ ITEYFSVLVN MDMSLHSMEV VNRLTTAVDL
   421  PPEFIHLYIS NCISTCEQIK DKYMQNRLVR LVCVFLQSLI RNKIINVQDL FIEVQAFCIE
   481  FSRIREAAGL FRLLKTLDTG ETPSETKMSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNOT11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 38 nTPM
  • esophagus: 36 nTPM
  • heart muscle: 35 nTPM
  • lymph node: 35 nTPM
  • rectum: 34 nTPM
  • bone marrow: 33 nTPM

Single-cell type

  • cytotrophoblasts: 87 nCPM
  • neutrophils: 83 nCPM
  • epicardial cells: 77 nCPM
  • migrating cytotrophoblasts: 73 nCPM
  • endometrial ciliated cells: 72 nCPM
  • endometrial glandular cells: 70 nCPM

Immune cell

  • basophil: 9.6 nTPM
  • neutrophil: 7.9 nTPM
  • T-reg: 4.5 nTPM
  • naive CD8 T-cell: 4.1 nTPM
  • eosinophil: 3.9 nTPM
  • memory CD8 T-cell: 3.8 nTPM

Brain region

  • choroid plexus: 29 nTPM
  • white matter: 24 nTPM
  • cerebellum: 23 nTPM
  • hypothalamus: 23 nTPM
  • cerebral cortex: 23 nTPM
  • pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.6
gnomAD missense Z
2.3
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • CCR4-NOT transcription complex subunit 11, C-terminal domain
  • CCR4-NOT transcription complex subunit 11

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNOT11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNOT11 as an antibody target. Whether an autoantibody or antibody against CNOT11 could matter depends on whether native CNOT11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNOT11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNOT11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CNOT11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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