Seroatlas · Human Serome Atlas

CPVL

Probable serine carboxypeptidase CPVL

Also known as: CPVL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3G5
Gene: CPVL
Ensembl: ENSG00000106066
Chromosome: 7
Canonical length: 476 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q9H3G5|CPVL
     1  MVGAMWKVIV SLVLLMPGPC DGLFRSLYRS VSMPPKGDSG QPLFLTPYIE AGKIQKGREL
    61  SLVGPFPGLN MKSYAGFLTV NKTYNSNLFF WFFPAQIQPE DAPVVLWLQG GPGGSSMFGL
   121  FVEHGPYVVT SNMTLRDRDF PWTTTLSMLY IDNPVGTGFS FTDDTHGYAV NEDDVARDLY
   181  SALIQFFQIF PEYKNNDFYV TGESYAGKYV PAIAHLIHSL NPVREVKINL NGIAIGDGYS
   241  DPESIIGGYA EFLYQIGLLD EKQKKYFQKQ CHECIEHIRK QNWFEAFEIL DKLLDGDLTS
   301  DPSYFQNVTG CSNYYNFLRC TEPEDQLYYV KFLSLPEVRQ AIHVGNQTFN DGTIVEKYLR
   361  EDTVQSVKPW LTEIMNNYKV LIYNGQLDII VAAALTERSL MGMDWKGSQE YKKAEKKVWK
   421  IFKSDSEVAG YIRQAGDFHQ VIIRGGGHIL PYDQPLRAFD MINRFIYGKG WDPYVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPVL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 206 nTPM

Expression across tissuesHPA

Tissue

spleen: 206 nTPM
choroid plexus: 192 nTPM
thyroid gland: 122 nTPM
kidney: 88 nTPM
lymph node: 87 nTPM
placenta: 80 nTPM

Single-cell type

cardiomyocytes: 1,565 nCPM
cdc: 1,103 nCPM
kupffer cells: 547 nCPM
hofbauer cells: 521 nCPM
macrophages: 423 nCPM
monocytes: 391 nCPM

Immune cell

myeloid DC: 1,322 nTPM
total PBMC: 1,143 nTPM
classical monocyte: 1,140 nTPM
intermediate monocyte: 955 nTPM
non-classical monocyte: 330 nTPM
plasmacytoid DC: 35 nTPM

Brain region

cerebellum: 101 nTPM
choroid plexus: 81 nTPM
white matter: 47 nTPM
medulla oblongata: 31 nTPM
pons: 29 nTPM
spinal cord: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CPVL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPVL as an antibody target. Whether an autoantibody or antibody against CPVL could matter depends on whether native CPVL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPVL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPVL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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