DBN1

Protein identityUniProt · HPA

UniProt accession

Q16643

Gene

DBN1

Ensembl

ENSG00000113758

Chromosome

5

Canonical length

649 aa

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane,Actin filaments

OverviewNCBI Gene

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

649 residues, UniProt reviewed canonical sequence.

>Q16643|DBN1
     1  MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG LQELSGHFEN
    61  QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS HVAKVAEFFQ GVDVIVNASS
   121  VEDIDAGAIG QRLSNGLARL SSPVLHRLRL REDENAEPVG TTYQKTDAAV EMKRINREQF
   181  WEQAKKEEEL RKEEERKKAL DERLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ
   241  TLEAEEAKRR LKEQSIFGDH RDEEEETHMK KSESEVEEAA AIIAQRPDNP REFFKQQERV
   301  ASASAGSCDV PSPFNHRPGS HLDSHRRMAP TPIPTRSPSD SSTASTPVAE QIERALDEVT
   361  SSQPPPLPPP PPPAQETQEP SPILDSEETR AAAPQAWAGP MEEPPQAQAP PRGPGSPAED
   421  LMFMESAEQA VLAAPVEPAT ADATEIHDAA DTIETDTATA DTTVANNVPP AATSLIDLWP
   481  GNGEGASTLQ GEPRAPTPPS GTEVTLAEVP LLDEVAPEPL LPAGEGCATL LNFDELPEPP
   541  ATFCDPEEVE GESLAAPQTP TLPSALEELE QEQEPEPHLL TNGETTQKEG TQASEGYFSQ
   601  SQEEEFAQSE ELCAKAPPPV FYNKPPEIDI TCWDADPVPE EEEGFEGGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DBN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.59

Highest tissue expression

74 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DBN1.

Disease | AllUniProt

Conditions DBN1 is implicated in, by any mechanism.

• Alzheimer disease (AD) MIM:104300

ReferencesPubMed · IEDB

Publications for DBN1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.26

gnomAD pLI

1

gnomAD missense Z

0.67

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin filament organization
• cell communication by chemical coupling
• cell communication by electrical coupling
• generation of neurons
• in utero embryonic development
• maintenance of protein location in cell
• neural precursor cell proliferation
• positive regulation of dendritic spine morphogenesis
• positive regulation of receptor localization to synapse
• positive regulation of synaptic plasticity
• regulation of dendrite development
• regulation of neuronal synaptic plasticity

Molecular functions

• actin binding
• cadherin binding
• profilin binding
• protein sequestering activity

Cellular components

• actin cytoskeleton
• actomyosin
• cortical cytoskeleton
• cytoplasm
• cytoskeleton
• dendrite
• gap junction
• glutamatergic synapse
• growth cone
• postsynaptic cytosol
• postsynaptic density
• postsynaptic membrane

Protein domainsUniProt · Pfam · InterPro

• Actin-depolymerising factor homology domain
• ADF-H/Gelsolin-like domain superfamily
• Cofilin/tropomyosin-type actin-binding protein

KeywordsUniProt

• Acetylation
• Actin-binding
• Alzheimer disease
• Amyloidosis
• Cell junction
• Cell projection
• Cytoplasm
• Developmental protein
• Differentiation
• Neurodegeneration
• Neurogenesis
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of DBN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CXCR4
• RUFY3
• CAPZB
• CTTN
• GRB2