Seroatlas · Human Serome Atlas

CAPZA2

F-actin-capping protein subunit alpha-2

Also known as: CAPPA2, CAPZ, CAZA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P47755
Gene: CAPZA2
Ensembl: ENSG00000198898
Chromosome: 7
Canonical length: 286 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

286 residues, UniProt reviewed canonical sequence.

>P47755|CAPZA2
     1  MADLEEQLSD EEKVRIAAKF IIHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNLD
    61  QFTPVKIEGY EDQVLITEHG DLGNGKFLDP KNRICFKFDH LRKEATDPRP CEVENAVESW
   121  RTSVETALRA YVKEHYPNGV CTVYGKKIDG QQTIIACIES HQFQAKNFWN GRWRSEWKFT
   181  ITPSTTQVVG ILKIQVHYYE DGNVQLVSHK DIQDSLTVSN EVQTAKEFIK IVEAAENEYQ
   241  TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPZA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 58 nTPM
tongue: 47 nTPM
heart muscle: 43 nTPM
bone marrow: 38 nTPM
kidney: 35 nTPM
liver: 31 nTPM

Single-cell type

neutrophils: 960 nCPM
platelets: 872 nCPM
endometrial glandular cells: 771 nCPM
megakaryocytes: 470 nCPM
endometrial luminal cells: 436 nCPM
hofbauer cells: 435 nCPM

Immune cell

neutrophil: 69 nTPM
basophil: 57 nTPM
non-classical monocyte: 55 nTPM
eosinophil: 46 nTPM
intermediate monocyte: 46 nTPM
total PBMC: 45 nTPM

Brain region

cerebellum: 36 nTPM
pons: 31 nTPM
hippocampal formation: 30 nTPM
cerebral cortex: 29 nTPM
thalamus: 28 nTPM
hypothalamus: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAPZA2.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 64 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 1.84
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin filament binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAPZA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPZA2 as an antibody target. Whether an autoantibody or antibody against CAPZA2 could matter depends on whether native CAPZA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPZA2 is annotated as secreted, so native CAPZA2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CAPZA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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