Seroatlas · Human Serome Atlas

RCSD1

CapZ-interacting protein

Also known as: CapZIP, CPZIP_HUMAN, MGC21854, MK2S4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6JBY9
Gene: RCSD1
Ensembl: ENSG00000198771
Chromosome: 1
Canonical length: 416 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables actin filament binding activity. Involved in cellular hyperosmotic response. Predicted to be located in actin filament. Predicted to be part of WASH complex. Predicted to be active in early endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>Q6JBY9|RCSD1
     1  MEERPAETNA NVDNSASPSV AQLAGRFREQ AAAAKETPAS KPTRRKPPCS LPLFPPKVDL
    61  GQNGEEKSPP NASHPPKFKV KSSPLIEKLQ ANLTFDPAAL LPGASPKSPG LKAMVSPFHS
   121  PPSTPSSPGV RSRPSEAEEV PVSFDQPPEG SHLPCYNKVR TRGSIKRRPP SRRFRRSQSD
   181  CGELGDFRAV ESSQQNGAKE EDGDEVLPSK SKAPGSPLSS EGAAGEGVRT LGPAEKPPLR
   241  RSPSRTEKQE EDRATEEAKN GEKARRSSEE VDGQHPAQEE VPESPQTSGP EAENRCGSPR
   301  EEKPAGEEAE MEKATEVKGE RVQNEEVGPE HDSQETKKLE EGAAVKETPH SPPGGVKGGD
   361  VPKQEKGKEK QQEGAVLEPG CSPQTGPAQL ETSSEVQSEP AVPKPEDDTP VQDTKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCSD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 139 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 139 nTPM
thymus: 108 nTPM
lymph node: 83 nTPM
tonsil: 69 nTPM
bone marrow: 53 nTPM
spleen: 49 nTPM

Single-cell type

b-cells: 558 nCPM
hematopoietic stem cells: 539 nCPM
thymocytes: 483 nCPM
microglia: 389 nCPM
neutrophil progenitors: 377 nCPM
kupffer cells: 346 nCPM

Immune cell

eosinophil: 272 nTPM
basophil: 251 nTPM
memory B-cell: 217 nTPM
naive B-cell: 202 nTPM
classical monocyte: 171 nTPM
neutrophil: 167 nTPM

Brain region

medulla oblongata: 18 nTPM
white matter: 18 nTPM
pons: 14 nTPM
thalamus: 13 nTPM
spinal cord: 11 nTPM
hypothalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.04
gnomAD missense Z: -0.44
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

FAM21/CAPZIP domain
WASH complex subunit CAP-Z interacting, central region
RCSD
RCSD region

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of RCSD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCSD1 as an antibody target. Whether an autoantibody or antibody against RCSD1 could matter depends on whether native RCSD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCSD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCSD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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